Periodontal Regeneration: Focus on Growth and Differentiation Factors

Jaebum Lee, Andreas Stavropoulos, Cristiano Susin, Ulf M E Wikesjö

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.

Original languageEnglish (US)
Pages (from-to)93-111
Number of pages19
JournalDental clinics of North America
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Growth Differentiation Factors
Regeneration
Wound Healing
Clinical Trials
Therapeutics
Research

Keywords

  • Differentiation factors
  • Growth factors
  • Periodontal regeneration
  • Preclinical study

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Periodontal Regeneration : Focus on Growth and Differentiation Factors. / Lee, Jaebum; Stavropoulos, Andreas; Susin, Cristiano; Wikesjö, Ulf M E.

In: Dental clinics of North America, Vol. 54, No. 1, 01.01.2010, p. 93-111.

Research output: Contribution to journalReview article

Lee, Jaebum ; Stavropoulos, Andreas ; Susin, Cristiano ; Wikesjö, Ulf M E. / Periodontal Regeneration : Focus on Growth and Differentiation Factors. In: Dental clinics of North America. 2010 ; Vol. 54, No. 1. pp. 93-111.
@article{9af331b9be2641e8b4904cde0b18fd1d,
title = "Periodontal Regeneration: Focus on Growth and Differentiation Factors",
abstract = "Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.",
keywords = "Differentiation factors, Growth factors, Periodontal regeneration, Preclinical study",
author = "Jaebum Lee and Andreas Stavropoulos and Cristiano Susin and Wikesj{\"o}, {Ulf M E}",
year = "2010",
month = "1",
day = "1",
doi = "10.1016/j.cden.2009.09.001",
language = "English (US)",
volume = "54",
pages = "93--111",
journal = "Dental Clinics of North America",
issn = "0011-8532",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Periodontal Regeneration

T2 - Focus on Growth and Differentiation Factors

AU - Lee, Jaebum

AU - Stavropoulos, Andreas

AU - Susin, Cristiano

AU - Wikesjö, Ulf M E

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.

AB - Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.

KW - Differentiation factors

KW - Growth factors

KW - Periodontal regeneration

KW - Preclinical study

UR - http://www.scopus.com/inward/record.url?scp=73249140940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73249140940&partnerID=8YFLogxK

U2 - 10.1016/j.cden.2009.09.001

DO - 10.1016/j.cden.2009.09.001

M3 - Review article

C2 - 20103474

AN - SCOPUS:73249140940

VL - 54

SP - 93

EP - 111

JO - Dental Clinics of North America

JF - Dental Clinics of North America

SN - 0011-8532

IS - 1

ER -