Periodontal repair in dogs: Space-provision supports alveolar bone and cementum formation

Hsien Chung Chiu, E. Chin Shen, Shu Jiun Lin, Cristiano Susin, Ulf M E Wikesjö, Earl Fu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective Clinical criteria for periodontal wound healing/regeneration include wound stability, space-provision and conditions for primary intention healing. However, wound stability/space-provision may be difficult to obtain in non-contained periodontal defects. The objective of this study was to; using a limited, space-providing device as a conduit, evaluate a concept of space-provision sans tissue occlusion for periodontal wound healing/ regeneration. Methods Bilateral, critical-size, supraalveolar, periodontal defects were created in eight young adult Beagle dogs. One jaw quadrant received a limited, space-providing titanium mesh device, the contra-lateral jaw quadrant served as sham-surgery control followed by submerged wound closure for primary intention healing. The animals were euthanized at 8 weeks for histometric analysis of the surgical sites. Results Clinical healing was generally uneventful; minor late exposures observed for some defects. Experimental sites exhibited significantly enhanced mean (±SE) bone and cementum regeneration compared with control (1.10 ± 0.20 and 1.32 ± 0.10 mm versus 0.34 ± 0.18 and 0.66 ± 0.15 mm; p < 0.01). A cellular mixed (extrinsic/intrinsic) fibre cementum and functionally oriented collagen fibres were routinely observed. Wound exposures were significantly associated with reduced bone formation (p < 0.05). Conclusions Using a limited, space-providing device to support periodontal wound healing/regeneration appears a promising clinical approach for non-contained periodontal defects.

Original languageEnglish (US)
Pages (from-to)358-363
Number of pages6
JournalJournal of Clinical Periodontology
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2013

Fingerprint

Dental Cementum
Osteogenesis
Dogs
Wound Healing
Regeneration
Wounds and Injuries
Jaw
Equipment and Supplies
Bone Regeneration
Titanium
Young Adult
Collagen

Keywords

  • alveolar bone
  • animal studies
  • barrier
  • cementum
  • guided tissue regeneration
  • periodontal ligament
  • periodontal regeneration
  • titanium mesh
  • wound healing

ASJC Scopus subject areas

  • Periodontics

Cite this

Chiu, H. C., Shen, E. C., Lin, S. J., Susin, C., Wikesjö, U. M. E., & Fu, E. (2013). Periodontal repair in dogs: Space-provision supports alveolar bone and cementum formation. Journal of Clinical Periodontology, 40(4), 358-363. https://doi.org/10.1111/jcpe.12071

Periodontal repair in dogs : Space-provision supports alveolar bone and cementum formation. / Chiu, Hsien Chung; Shen, E. Chin; Lin, Shu Jiun; Susin, Cristiano; Wikesjö, Ulf M E; Fu, Earl.

In: Journal of Clinical Periodontology, Vol. 40, No. 4, 01.04.2013, p. 358-363.

Research output: Contribution to journalArticle

Chiu, Hsien Chung ; Shen, E. Chin ; Lin, Shu Jiun ; Susin, Cristiano ; Wikesjö, Ulf M E ; Fu, Earl. / Periodontal repair in dogs : Space-provision supports alveolar bone and cementum formation. In: Journal of Clinical Periodontology. 2013 ; Vol. 40, No. 4. pp. 358-363.
@article{53b0e7c1a14944169190d0bfdd8df735,
title = "Periodontal repair in dogs: Space-provision supports alveolar bone and cementum formation",
abstract = "Objective Clinical criteria for periodontal wound healing/regeneration include wound stability, space-provision and conditions for primary intention healing. However, wound stability/space-provision may be difficult to obtain in non-contained periodontal defects. The objective of this study was to; using a limited, space-providing device as a conduit, evaluate a concept of space-provision sans tissue occlusion for periodontal wound healing/ regeneration. Methods Bilateral, critical-size, supraalveolar, periodontal defects were created in eight young adult Beagle dogs. One jaw quadrant received a limited, space-providing titanium mesh device, the contra-lateral jaw quadrant served as sham-surgery control followed by submerged wound closure for primary intention healing. The animals were euthanized at 8 weeks for histometric analysis of the surgical sites. Results Clinical healing was generally uneventful; minor late exposures observed for some defects. Experimental sites exhibited significantly enhanced mean (±SE) bone and cementum regeneration compared with control (1.10 ± 0.20 and 1.32 ± 0.10 mm versus 0.34 ± 0.18 and 0.66 ± 0.15 mm; p < 0.01). A cellular mixed (extrinsic/intrinsic) fibre cementum and functionally oriented collagen fibres were routinely observed. Wound exposures were significantly associated with reduced bone formation (p < 0.05). Conclusions Using a limited, space-providing device to support periodontal wound healing/regeneration appears a promising clinical approach for non-contained periodontal defects.",
keywords = "alveolar bone, animal studies, barrier, cementum, guided tissue regeneration, periodontal ligament, periodontal regeneration, titanium mesh, wound healing",
author = "Chiu, {Hsien Chung} and Shen, {E. Chin} and Lin, {Shu Jiun} and Cristiano Susin and Wikesj{\"o}, {Ulf M E} and Earl Fu",
year = "2013",
month = "4",
day = "1",
doi = "10.1111/jcpe.12071",
language = "English (US)",
volume = "40",
pages = "358--363",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Blackwell Munksgaard",
number = "4",

}

TY - JOUR

T1 - Periodontal repair in dogs

T2 - Space-provision supports alveolar bone and cementum formation

AU - Chiu, Hsien Chung

AU - Shen, E. Chin

AU - Lin, Shu Jiun

AU - Susin, Cristiano

AU - Wikesjö, Ulf M E

AU - Fu, Earl

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Objective Clinical criteria for periodontal wound healing/regeneration include wound stability, space-provision and conditions for primary intention healing. However, wound stability/space-provision may be difficult to obtain in non-contained periodontal defects. The objective of this study was to; using a limited, space-providing device as a conduit, evaluate a concept of space-provision sans tissue occlusion for periodontal wound healing/ regeneration. Methods Bilateral, critical-size, supraalveolar, periodontal defects were created in eight young adult Beagle dogs. One jaw quadrant received a limited, space-providing titanium mesh device, the contra-lateral jaw quadrant served as sham-surgery control followed by submerged wound closure for primary intention healing. The animals were euthanized at 8 weeks for histometric analysis of the surgical sites. Results Clinical healing was generally uneventful; minor late exposures observed for some defects. Experimental sites exhibited significantly enhanced mean (±SE) bone and cementum regeneration compared with control (1.10 ± 0.20 and 1.32 ± 0.10 mm versus 0.34 ± 0.18 and 0.66 ± 0.15 mm; p < 0.01). A cellular mixed (extrinsic/intrinsic) fibre cementum and functionally oriented collagen fibres were routinely observed. Wound exposures were significantly associated with reduced bone formation (p < 0.05). Conclusions Using a limited, space-providing device to support periodontal wound healing/regeneration appears a promising clinical approach for non-contained periodontal defects.

AB - Objective Clinical criteria for periodontal wound healing/regeneration include wound stability, space-provision and conditions for primary intention healing. However, wound stability/space-provision may be difficult to obtain in non-contained periodontal defects. The objective of this study was to; using a limited, space-providing device as a conduit, evaluate a concept of space-provision sans tissue occlusion for periodontal wound healing/ regeneration. Methods Bilateral, critical-size, supraalveolar, periodontal defects were created in eight young adult Beagle dogs. One jaw quadrant received a limited, space-providing titanium mesh device, the contra-lateral jaw quadrant served as sham-surgery control followed by submerged wound closure for primary intention healing. The animals were euthanized at 8 weeks for histometric analysis of the surgical sites. Results Clinical healing was generally uneventful; minor late exposures observed for some defects. Experimental sites exhibited significantly enhanced mean (±SE) bone and cementum regeneration compared with control (1.10 ± 0.20 and 1.32 ± 0.10 mm versus 0.34 ± 0.18 and 0.66 ± 0.15 mm; p < 0.01). A cellular mixed (extrinsic/intrinsic) fibre cementum and functionally oriented collagen fibres were routinely observed. Wound exposures were significantly associated with reduced bone formation (p < 0.05). Conclusions Using a limited, space-providing device to support periodontal wound healing/regeneration appears a promising clinical approach for non-contained periodontal defects.

KW - alveolar bone

KW - animal studies

KW - barrier

KW - cementum

KW - guided tissue regeneration

KW - periodontal ligament

KW - periodontal regeneration

KW - titanium mesh

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=84875232054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875232054&partnerID=8YFLogxK

U2 - 10.1111/jcpe.12071

DO - 10.1111/jcpe.12071

M3 - Article

C2 - 23410055

AN - SCOPUS:84875232054

VL - 40

SP - 358

EP - 363

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 4

ER -