Permeating the blood brain barrier and Abrogating the inflammation in stroke: Implications for stroke therapy

Cesar V. Borlongan, Loren E. Glover, P. R. Sanberg, David C. Hess

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Cell therapy has been shown as a potential treatment for stroke and other neurological disorders. Human umbilical cord blood (HUCB) may be a promising source of stem cells for cell therapy. The most desired outcomes occur when stem cells cross the blood brain barrier (BBB) and eventually reach the injured brain site. We propose, from our previous studies, that mannitol is capable of disrupting the BBB, allowing the transplanted cells to enter the brain from the periphery. However, when the BBB is compromised, the inflammatory response from circulation may also be able to penetrate the brain and thus may actually exacerbate the stroke rather than afford therapeutic effects. We discuss how an NF-kB decoy can inhibit the inflammatory responses in the stroke brain thereby reducing the negative effects associated with BBB disruption. In this review, we propose the combination of mannitol-induced BBB permeation and NF-kB decoy for enhancing the therapeutic benefits of cell therapy in stroke.

Original languageEnglish (US)
Pages (from-to)3670-3676
Number of pages7
JournalCurrent Pharmaceutical Design
Volume18
Issue number25
DOIs
StatePublished - 2012

Keywords

  • Blood brain barrier
  • Cerebral palsy
  • Mannitol
  • NF-kB
  • Neurotrophic factor
  • Stem cells
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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