Perspective on fever: The basic science and conventional medicine

Joseph G. Cannon

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.

Original languageEnglish (US)
Pages (from-to)S54-S60
JournalComplementary Therapies in Medicine
Issue numberSUPPL.1
StatePublished - Apr 2013


  • Cytokines
  • Fever
  • Thermoregulation

ASJC Scopus subject areas

  • Complementary and Manual Therapy
  • Complementary and alternative medicine
  • Advanced and Specialized Nursing


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