Abstract
Interleukin-7 has critical and nonredundant roles in T cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple therapeutic applications in immunodeficiency states, either physiologic (immuno-senescence), pathologic (HIV) or iatrogenic (postchemotherapy and posthematopoietic stem cell transplant) and may have roles in immune reconstitution or enhancement of immunotherapy. Early clinical development trials in humans show that, within a short time, rhIL-7 administration results in a marked preferential expansion of both naive and memory CD4 and CD8 T cell pools with a tendency toward enhanced CD8 expansion. As a result, lymphopenic or normal older hosts develop an expanded circulating T cell pool with a profile that resembles that seen earlier in life with increased T cell repertoire diversity. These results, along with a favorable toxicity profile, open a wide perspective of potential future clinical applications.
| Original language | English (US) |
|---|---|
| Title of host publication | Cytokine Therapies Novel Approaches for Clinical Indications |
| Publisher | Blackwell Publishing Inc. |
| Pages | 28-38 |
| Number of pages | 11 |
| ISBN (Print) | 9781573317832 |
| DOIs | |
| State | Published - Jan 1 2009 |
| Externally published | Yes |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1182 |
| ISSN (Print) | 0077-8923 |
| ISSN (Electronic) | 1749-6632 |
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Keywords
- Cytokine
- Interleukin
- T cell
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Perspective on potential clinical applications of recombinant human interleukin-7. / Sportes, Claude; Gress, Ronald E.; Mackall, Crystal L.
Cytokine Therapies Novel Approaches for Clinical Indications. Blackwell Publishing Inc., 2009. p. 28-38 (Annals of the New York Academy of Sciences; Vol. 1182).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Perspective on potential clinical applications of recombinant human interleukin-7
AU - Sportes, Claude
AU - Gress, Ronald E.
AU - Mackall, Crystal L.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Interleukin-7 has critical and nonredundant roles in T cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple therapeutic applications in immunodeficiency states, either physiologic (immuno-senescence), pathologic (HIV) or iatrogenic (postchemotherapy and posthematopoietic stem cell transplant) and may have roles in immune reconstitution or enhancement of immunotherapy. Early clinical development trials in humans show that, within a short time, rhIL-7 administration results in a marked preferential expansion of both naive and memory CD4 and CD8 T cell pools with a tendency toward enhanced CD8 expansion. As a result, lymphopenic or normal older hosts develop an expanded circulating T cell pool with a profile that resembles that seen earlier in life with increased T cell repertoire diversity. These results, along with a favorable toxicity profile, open a wide perspective of potential future clinical applications.
AB - Interleukin-7 has critical and nonredundant roles in T cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple therapeutic applications in immunodeficiency states, either physiologic (immuno-senescence), pathologic (HIV) or iatrogenic (postchemotherapy and posthematopoietic stem cell transplant) and may have roles in immune reconstitution or enhancement of immunotherapy. Early clinical development trials in humans show that, within a short time, rhIL-7 administration results in a marked preferential expansion of both naive and memory CD4 and CD8 T cell pools with a tendency toward enhanced CD8 expansion. As a result, lymphopenic or normal older hosts develop an expanded circulating T cell pool with a profile that resembles that seen earlier in life with increased T cell repertoire diversity. These results, along with a favorable toxicity profile, open a wide perspective of potential future clinical applications.
KW - Cytokine
KW - Interleukin
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=73849138583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73849138583&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05075.x
DO - 10.1111/j.1749-6632.2009.05075.x
M3 - Conference contribution
SN - 9781573317832
T3 - Annals of the New York Academy of Sciences
SP - 28
EP - 38
BT - Cytokine Therapies Novel Approaches for Clinical Indications
PB - Blackwell Publishing Inc.
ER -