@inproceedings{a4865f85070143cead682054943bc09f,
title = "Perspective on potential clinical applications of recombinant human interleukin-7",
abstract = "Interleukin-7 has critical and nonredundant roles in T cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple therapeutic applications in immunodeficiency states, either physiologic (immuno-senescence), pathologic (HIV) or iatrogenic (postchemotherapy and posthematopoietic stem cell transplant) and may have roles in immune reconstitution or enhancement of immunotherapy. Early clinical development trials in humans show that, within a short time, rhIL-7 administration results in a marked preferential expansion of both naive and memory CD4 and CD8 T cell pools with a tendency toward enhanced CD8 expansion. As a result, lymphopenic or normal older hosts develop an expanded circulating T cell pool with a profile that resembles that seen earlier in life with increased T cell repertoire diversity. These results, along with a favorable toxicity profile, open a wide perspective of potential future clinical applications.",
keywords = "Cytokine, Interleukin, T cell",
author = "Claude Sport{\`e}s and Gress, {Ronald E.} and Mackall, {Crystal L.}",
note = "Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2009",
doi = "10.1111/j.1749-6632.2009.05075.x",
language = "English (US)",
isbn = "9781573317832",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "28--38",
booktitle = "Cytokine Therapies Novel Approaches for Clinical Indications",
}