Perspective on potential clinical applications of recombinant human interleukin-7

Claude Sportès, Ronald E. Gress, Crystal L. Mackall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Scopus citations

Abstract

Interleukin-7 has critical and nonredundant roles in T cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple therapeutic applications in immunodeficiency states, either physiologic (immuno-senescence), pathologic (HIV) or iatrogenic (postchemotherapy and posthematopoietic stem cell transplant) and may have roles in immune reconstitution or enhancement of immunotherapy. Early clinical development trials in humans show that, within a short time, rhIL-7 administration results in a marked preferential expansion of both naive and memory CD4 and CD8 T cell pools with a tendency toward enhanced CD8 expansion. As a result, lymphopenic or normal older hosts develop an expanded circulating T cell pool with a profile that resembles that seen earlier in life with increased T cell repertoire diversity. These results, along with a favorable toxicity profile, open a wide perspective of potential future clinical applications.

Original languageEnglish (US)
Title of host publicationCytokine Therapies Novel Approaches for Clinical Indications
PublisherBlackwell Publishing Inc.
Pages28-38
Number of pages11
ISBN (Print)9781573317832
DOIs
StatePublished - 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1182
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Cytokine
  • Interleukin
  • T cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Sportès, C., Gress, R. E., & Mackall, C. L. (2009). Perspective on potential clinical applications of recombinant human interleukin-7. In Cytokine Therapies Novel Approaches for Clinical Indications (pp. 28-38). (Annals of the New York Academy of Sciences; Vol. 1182). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05075.x