Pharmacologic Management of Chronic Constipation

Siddharth Singh, Satish Sanku Chander Rao

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Chronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications. Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients. Several newer agents that act by increasing colonic peristalsis, altering colonic secretion, and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life. This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation.

Original languageEnglish (US)
Pages (from-to)509-527
Number of pages19
JournalGastroenterology Clinics of North America
Volume39
Issue number3
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

Fingerprint

Constipation
Peristalsis
Laxatives
Opioid Receptors
North America
Life Style
Quality of Life
Pharmacology
Costs and Cost Analysis
Therapeutics

Keywords

  • Alvimopan
  • Chronic constipation
  • Laxatives
  • Linaclotide
  • Lubiprostone
  • Medical management
  • Methylnaltrexone
  • Prucalopride

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pharmacologic Management of Chronic Constipation. / Singh, Siddharth; Rao, Satish Sanku Chander.

In: Gastroenterology Clinics of North America, Vol. 39, No. 3, 01.09.2010, p. 509-527.

Research output: Contribution to journalReview article

@article{e37bab817563477ab074f59b32221af2,
title = "Pharmacologic Management of Chronic Constipation",
abstract = "Chronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications. Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients. Several newer agents that act by increasing colonic peristalsis, altering colonic secretion, and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life. This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation.",
keywords = "Alvimopan, Chronic constipation, Laxatives, Linaclotide, Lubiprostone, Medical management, Methylnaltrexone, Prucalopride",
author = "Siddharth Singh and Rao, {Satish Sanku Chander}",
year = "2010",
month = "9",
day = "1",
doi = "10.1016/j.gtc.2010.08.001",
language = "English (US)",
volume = "39",
pages = "509--527",
journal = "Gastroenterology Clinics of North America",
issn = "0889-8553",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Pharmacologic Management of Chronic Constipation

AU - Singh, Siddharth

AU - Rao, Satish Sanku Chander

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Chronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications. Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients. Several newer agents that act by increasing colonic peristalsis, altering colonic secretion, and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life. This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation.

AB - Chronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications. Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients. Several newer agents that act by increasing colonic peristalsis, altering colonic secretion, and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life. This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation.

KW - Alvimopan

KW - Chronic constipation

KW - Laxatives

KW - Linaclotide

KW - Lubiprostone

KW - Medical management

KW - Methylnaltrexone

KW - Prucalopride

UR - http://www.scopus.com/inward/record.url?scp=77957922292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957922292&partnerID=8YFLogxK

U2 - 10.1016/j.gtc.2010.08.001

DO - 10.1016/j.gtc.2010.08.001

M3 - Review article

VL - 39

SP - 509

EP - 527

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

SN - 0889-8553

IS - 3

ER -