Phenformin: AMP(K)ed for Potential Repurposing

Joo Jung, Wendy B. Bollag

Research output: Contribution to journalComment/debatepeer-review

Abstract

The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are described. Thus, the proposed repurposing of phenformin to treat skin cancer has merit.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalJournal of Investigative Dermatology
Volume141
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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