Phenytoin potentiation of neuroleptic‐induced dyskinesias

K. D. Sethi; Ana Hitri; Bruce I. Diamond

doi:10.1002/mds.870050413

Phenytoin potentiation of neuroleptic‐induced dyskinesias

K. D. Sethi, Ana Hitri, Bruce I. Diamond

Neurology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Clinically phenytoin‐induced movement disorders may resemble neuroleptic‐induced tardive dyskinesia (TD). Neuroleptic‐induced TD is thought to be related to an increase in the number and affinity of dopamine D₂ receptors. We investigated the interaction of phenytoin with dopaminergic systems by measuring dopamine behavior and receptor changes in animals treated with phenytoin alone or in combination with chlorpromazine. Phenytoin alone or in combination produced significant behavioral supersensitivity without alteration of dopamine D2 receptor density or affinity. This animal study suggests that phenytoin may aggravate neuroleptic‐induced tardive dyskinesia through mechanisms other than the dopamine D₂ receptors.

Original language	English (US)
Pages (from-to)	325-327
Number of pages	3
Journal	Movement Disorders
Volume	5
Issue number	4
DOIs	https://doi.org/10.1002/mds.870050413
State	Published - 1990

Keywords

Neuroleptic dyskinesias
Phenytoin

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.870050413

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abstract = "Clinically phenytoin‐induced movement disorders may resemble neuroleptic‐induced tardive dyskinesia (TD). Neuroleptic‐induced TD is thought to be related to an increase in the number and affinity of dopamine D2 receptors. We investigated the interaction of phenytoin with dopaminergic systems by measuring dopamine behavior and receptor changes in animals treated with phenytoin alone or in combination with chlorpromazine. Phenytoin alone or in combination produced significant behavioral supersensitivity without alteration of dopamine D2 receptor density or affinity. This animal study suggests that phenytoin may aggravate neuroleptic‐induced tardive dyskinesia through mechanisms other than the dopamine D2 receptors.",

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AU - Sethi, K. D.

AU - Hitri, Ana

AU - Diamond, Bruce I.

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AB - Clinically phenytoin‐induced movement disorders may resemble neuroleptic‐induced tardive dyskinesia (TD). Neuroleptic‐induced TD is thought to be related to an increase in the number and affinity of dopamine D2 receptors. We investigated the interaction of phenytoin with dopaminergic systems by measuring dopamine behavior and receptor changes in animals treated with phenytoin alone or in combination with chlorpromazine. Phenytoin alone or in combination produced significant behavioral supersensitivity without alteration of dopamine D2 receptor density or affinity. This animal study suggests that phenytoin may aggravate neuroleptic‐induced tardive dyskinesia through mechanisms other than the dopamine D2 receptors.

KW - Neuroleptic dyskinesias

KW - Phenytoin

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Phenytoin potentiation of neuroleptic‐induced dyskinesias

Abstract

Keywords

ASJC Scopus subject areas

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