Plaque fluoride concentrations in a community without water fluoridation: Effects of calcium and use of a fluoride or placebo dentifrice

Gary M. Whitford, M. A R Buzalaf, M. F B Bijella, Jennifer L Waller

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30 Scopus citations


The results of a recent study by Whitford et al. [Caries Res 2002;36:256-265] with subjects whose drinking water was fluoridated led to two major conclusions: (1) Compared to the use of a placebo dentifrice, plaque fluoride concentrations ([F]) throughout much of the day are not significantly increased by the use of an F dentifrice but (2) they are positively related to plaque [Ca] (p = 0.0001). The present double-blind, double-crossover study with 16 subjects used the same protocol and was done to: (1) determine the effects of the use of an F dentifrice on salivary and plaque [F] in a community without water fluoridation and (2) further examine the relationship between plaque [Ca] and [F]. Following the use of an F dentifrice or placebo for one week, whole saliva and plaque were collected 1.0 and 12 h after the last use of the products. The study was repeated to include rinsing with a 20 mmol/l CaCl 2 solution immediately before the use of the dentifrices. The CaCl2 rinse had only minor effects on salivary [Ca] and [F] and none on the plaque concentrations. Unlike the results found in the fluoridated community, all salivary and plaque [F] associated with the use of the F dentifrice were significantly higher than those associated with the use of the placebo. The results suggest that the cariostatic effectiveness of an F dentifrice should be greater in areas without water fluoridation. As noted previously, plaque [F] were positively related to plaque [Ca] (p = 0.0001).

Original languageEnglish (US)
Pages (from-to)100-107
Number of pages8
JournalCaries Research
Issue number2
Publication statusPublished - Mar 1 2005



  • Calcium
  • Dental caries
  • Dental plaque
  • Fluoridated dentifrice
  • Fluoride
  • Water fluoridation

ASJC Scopus subject areas

  • Dentistry(all)

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