Plasma lipoproteins in cortical versus lacunar infarction

Robert J. Adams, Richard M. Carroll, Fenwick T Nichols, Nancy Lynn McNair, Daniel S. Feldman, Elaine B. Feldman, William O. Thompson

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We investigated the relation of plasma lipids to the risk for ischemic stroke by comparing clinical and biochemical characteristics of survivors of cortical (n=48) and lacunar (n=36) brain infarction. By analysis of variance, no differences were observed in the concentrations of total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, or apoproteins At and B. Patients with lacunar infarction, however, had higher concentrations of high density lipoprotein (HDL)-cholesterol than patients with cortical stroke. This HDI.-cholesterol difference was due primarily to a strikingly low HDL-cholesterol content in white patients with cortical stroke. These data suggest that previously demonstrated differences in HDL-cholesterol concentrations between patients with ischemic stroke and control subjects without stroke may apply to patients with cortical but not lacunar infarction. Separation of cerebral infarction Into subtypes based on mechanism may help clarify lipid- related risk factors in cerebrovascular disease.

Original languageEnglish (US)
Pages (from-to)448-452
Number of pages5
JournalStroke
Volume20
Issue number4
DOIs
StatePublished - Jan 1 1989

Fingerprint

Lacunar Stroke
Lipoproteins
Stroke
HDL Cholesterol
LDL Cholesterol
Cholesterol
Brain Infarction
Lipids
Cerebrovascular Disorders
VLDL Cholesterol
Cerebral Infarction
Apolipoproteins B
Survivors
Analysis of Variance
Triglycerides

Keywords

  • Cerebral infarction
  • Cholesterol
  • Lacunar infarction
  • Lipids

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Adams, R. J., Carroll, R. M., Nichols, F. T., McNair, N. L., Feldman, D. S., Feldman, E. B., & Thompson, W. O. (1989). Plasma lipoproteins in cortical versus lacunar infarction. Stroke, 20(4), 448-452. https://doi.org/10.1161/01.STR.20.4.448

Plasma lipoproteins in cortical versus lacunar infarction. / Adams, Robert J.; Carroll, Richard M.; Nichols, Fenwick T; McNair, Nancy Lynn; Feldman, Daniel S.; Feldman, Elaine B.; Thompson, William O.

In: Stroke, Vol. 20, No. 4, 01.01.1989, p. 448-452.

Research output: Contribution to journalArticle

Adams, RJ, Carroll, RM, Nichols, FT, McNair, NL, Feldman, DS, Feldman, EB & Thompson, WO 1989, 'Plasma lipoproteins in cortical versus lacunar infarction', Stroke, vol. 20, no. 4, pp. 448-452. https://doi.org/10.1161/01.STR.20.4.448
Adams, Robert J. ; Carroll, Richard M. ; Nichols, Fenwick T ; McNair, Nancy Lynn ; Feldman, Daniel S. ; Feldman, Elaine B. ; Thompson, William O. / Plasma lipoproteins in cortical versus lacunar infarction. In: Stroke. 1989 ; Vol. 20, No. 4. pp. 448-452.
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