Plasmablastic lymphoma: CNS involvement, coexistence of other malignancies, possible viral etiology, and dismal outcome

Celalettin Ustun, Michelle Reid-Nicholson, Asha Nayak-Kapoor, Jennifer Jones-Crawford, Kristy McDonald, Anand P. Jillella, Preetha Ramalingam

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The clinical and pathological findings of plasmablastic lymphoma (PBL) have been described in the literature but the etiology is not well established, and treatment options are poorly defined. We reviewed patients with PBL in our institution to characterize the clinicopathologic features in our patient population. In this retrospective analysis from a single academic institution, five patients with PBL were identified and analyzed. Human immunodeficiency virus and human herpesvirus 8 (HHV-8) were identified in 40% (two out of five) and 80% (four out of five) of these patients, respectively. Central nervous system (CNS) involvement was identified in four out of five (80%) patients. Interestingly, three out of five patients had a concurrent or preceding second primary malignancy including small lymphocytic lymphoma, endometrial cancer, and nonsmall cell lung cancer. Most of the patients had advanced disease and a poor performance status at diagnosis. Only two of the patients received systemic chemotherapy with an initial partial response. All five patients died; the median overall survival was 1 month. Our experience in patients with PBL indicates that CNS involvement is more common than reported in the literature. Coexistence of a second primary malignancy may be frequent, and prognosis remains dismal with standard lymphoma therapy. Lastly, the role of HHV-8 in the etiopathogenesis needs further trials.

Original languageEnglish (US)
Pages (from-to)351-358
Number of pages8
JournalAnnals of Hematology
Volume88
Issue number4
DOIs
StatePublished - Jan 1 2009

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Central Nervous System
Neoplasms
Human Herpesvirus 8
Second Primary Neoplasms
Plasmablastic Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Endometrial Neoplasms
Non-Small Cell Lung Carcinoma
Lymphoma
HIV
Drug Therapy
Survival
Therapeutics
Population

Keywords

  • CNS involvement
  • HHV-8
  • HIV
  • Plasmablastic lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Plasmablastic lymphoma : CNS involvement, coexistence of other malignancies, possible viral etiology, and dismal outcome. / Ustun, Celalettin; Reid-Nicholson, Michelle; Nayak-Kapoor, Asha; Jones-Crawford, Jennifer; McDonald, Kristy; Jillella, Anand P.; Ramalingam, Preetha.

In: Annals of Hematology, Vol. 88, No. 4, 01.01.2009, p. 351-358.

Research output: Contribution to journalArticle

Ustun, Celalettin ; Reid-Nicholson, Michelle ; Nayak-Kapoor, Asha ; Jones-Crawford, Jennifer ; McDonald, Kristy ; Jillella, Anand P. ; Ramalingam, Preetha. / Plasmablastic lymphoma : CNS involvement, coexistence of other malignancies, possible viral etiology, and dismal outcome. In: Annals of Hematology. 2009 ; Vol. 88, No. 4. pp. 351-358.
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