Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population

Mei Qu, Weihua Yue, Fulei Tang, Lifang Wang, Yonghua Han, Dai Zhang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Several recent studies have provided evidence that abnormalities in oligodendrocyte and myelin function may contribute to the etiopathology of schizophrenia. Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of oligodendrocytes, has been identified as down-regulated expression in schizophrenia brain by microarray, quantitative PCR and in situ hybridization method. In order to further assess the role of TF in schizophrenia, we examined seven polymorphisms in TF region using a set sample of Chinese Han subjects consisting of 326 schizophrenia patients and 344 healthy controls. Four single nucleotide polymorphisms (SNPs) namely, rs4481157, rs3811655, rs6762415 and rs1405022 were analyzed in this study. Our results showed that one intronic SNP had strong association with schizophrenia (rs3811655: allele C > G, P = 1.34E-6, OR = 1.89, 95% CI = 1.46-2.46; genotype P = 3.72E-6). Two haplotypes A-C and G-G constructed of rs4481157-rs3811655 also revealed significant associations with schizophrenia (global P = 0.0001). Our findings support that TF gene may be involved in susceptibility to schizophrenia in the Chinese Han population. However, further studies are needed to confirm these findings in other populations and to identify functional variants in TF that may be implicated in pathogenesis.

Original languageEnglish (US)
Pages (from-to)877-883
Number of pages7
JournalJournal of Psychiatric Research
Volume42
Issue number11
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

Fingerprint

Transferrin
Schizophrenia
Population
Genes
Oligodendroglia
Myelin Sheath
Single Nucleotide Polymorphism
Haplotypes
In Situ Hybridization
Glycoproteins
Iron
Alleles
Genotype
Polymerase Chain Reaction
Brain

Keywords

  • Haplotype
  • Linkage disequilibrium
  • Myelination
  • Schizophrenia
  • Transferrin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population. / Qu, Mei; Yue, Weihua; Tang, Fulei; Wang, Lifang; Han, Yonghua; Zhang, Dai.

In: Journal of Psychiatric Research, Vol. 42, No. 11, 01.09.2008, p. 877-883.

Research output: Contribution to journalArticle

Qu, Mei ; Yue, Weihua ; Tang, Fulei ; Wang, Lifang ; Han, Yonghua ; Zhang, Dai. / Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population. In: Journal of Psychiatric Research. 2008 ; Vol. 42, No. 11. pp. 877-883.
@article{fa346d89b83c44d1991087c6718d7b74,
title = "Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population",
abstract = "Several recent studies have provided evidence that abnormalities in oligodendrocyte and myelin function may contribute to the etiopathology of schizophrenia. Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of oligodendrocytes, has been identified as down-regulated expression in schizophrenia brain by microarray, quantitative PCR and in situ hybridization method. In order to further assess the role of TF in schizophrenia, we examined seven polymorphisms in TF region using a set sample of Chinese Han subjects consisting of 326 schizophrenia patients and 344 healthy controls. Four single nucleotide polymorphisms (SNPs) namely, rs4481157, rs3811655, rs6762415 and rs1405022 were analyzed in this study. Our results showed that one intronic SNP had strong association with schizophrenia (rs3811655: allele C > G, P = 1.34E-6, OR = 1.89, 95{\%} CI = 1.46-2.46; genotype P = 3.72E-6). Two haplotypes A-C and G-G constructed of rs4481157-rs3811655 also revealed significant associations with schizophrenia (global P = 0.0001). Our findings support that TF gene may be involved in susceptibility to schizophrenia in the Chinese Han population. However, further studies are needed to confirm these findings in other populations and to identify functional variants in TF that may be implicated in pathogenesis.",
keywords = "Haplotype, Linkage disequilibrium, Myelination, Schizophrenia, Transferrin",
author = "Mei Qu and Weihua Yue and Fulei Tang and Lifang Wang and Yonghua Han and Dai Zhang",
year = "2008",
month = "9",
day = "1",
doi = "10.1016/j.jpsychires.2007.10.005",
language = "English (US)",
volume = "42",
pages = "877--883",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population

AU - Qu, Mei

AU - Yue, Weihua

AU - Tang, Fulei

AU - Wang, Lifang

AU - Han, Yonghua

AU - Zhang, Dai

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Several recent studies have provided evidence that abnormalities in oligodendrocyte and myelin function may contribute to the etiopathology of schizophrenia. Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of oligodendrocytes, has been identified as down-regulated expression in schizophrenia brain by microarray, quantitative PCR and in situ hybridization method. In order to further assess the role of TF in schizophrenia, we examined seven polymorphisms in TF region using a set sample of Chinese Han subjects consisting of 326 schizophrenia patients and 344 healthy controls. Four single nucleotide polymorphisms (SNPs) namely, rs4481157, rs3811655, rs6762415 and rs1405022 were analyzed in this study. Our results showed that one intronic SNP had strong association with schizophrenia (rs3811655: allele C > G, P = 1.34E-6, OR = 1.89, 95% CI = 1.46-2.46; genotype P = 3.72E-6). Two haplotypes A-C and G-G constructed of rs4481157-rs3811655 also revealed significant associations with schizophrenia (global P = 0.0001). Our findings support that TF gene may be involved in susceptibility to schizophrenia in the Chinese Han population. However, further studies are needed to confirm these findings in other populations and to identify functional variants in TF that may be implicated in pathogenesis.

AB - Several recent studies have provided evidence that abnormalities in oligodendrocyte and myelin function may contribute to the etiopathology of schizophrenia. Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of oligodendrocytes, has been identified as down-regulated expression in schizophrenia brain by microarray, quantitative PCR and in situ hybridization method. In order to further assess the role of TF in schizophrenia, we examined seven polymorphisms in TF region using a set sample of Chinese Han subjects consisting of 326 schizophrenia patients and 344 healthy controls. Four single nucleotide polymorphisms (SNPs) namely, rs4481157, rs3811655, rs6762415 and rs1405022 were analyzed in this study. Our results showed that one intronic SNP had strong association with schizophrenia (rs3811655: allele C > G, P = 1.34E-6, OR = 1.89, 95% CI = 1.46-2.46; genotype P = 3.72E-6). Two haplotypes A-C and G-G constructed of rs4481157-rs3811655 also revealed significant associations with schizophrenia (global P = 0.0001). Our findings support that TF gene may be involved in susceptibility to schizophrenia in the Chinese Han population. However, further studies are needed to confirm these findings in other populations and to identify functional variants in TF that may be implicated in pathogenesis.

KW - Haplotype

KW - Linkage disequilibrium

KW - Myelination

KW - Schizophrenia

KW - Transferrin

UR - http://www.scopus.com/inward/record.url?scp=47649123676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47649123676&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychires.2007.10.005

DO - 10.1016/j.jpsychires.2007.10.005

M3 - Article

VL - 42

SP - 877

EP - 883

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 11

ER -