Population-based geospatial and molecular epidemiologic study of tuberculosis transmission dynamics, Botswana, 2012–2016

Nicola M. Zetola, Patrick K. Moonan, Eleanor Click, John E. Oeltmann, Joyce Basotli, Xiao Jun Wen, Rosanna Boyd, James L. Tobias, Alyssa Finlay, Chawangwa Modongo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012–March 2016, all patients who had TB were enrolled, their sputum samples were cultured, and M. tuberculosis isolates were genotyped by using 24-locus mycobacterial interspersed repetitive units–variable number of tandem repeats. Of 5,515 TB patients, 4,331 (79%) were enrolled. Annualized TB incidence varied by geography (range 66–1,140 TB patients/100,000 persons). A total of 1,796 patient isolates had valid genotyping results and residential geocoordinates; 780 (41%) patients were involved in a localized TB transmission event. Residence in areas with a high burden of TB, age <24 years, being a current smoker, and unemployment were factors associated with localized transmission events. Patients with known HIV-positive status had lower odds of being involved in localized transmission.

Original languageEnglish (US)
Pages (from-to)835-844
Number of pages10
JournalEmerging Infectious Diseases
Volume27
Issue number3
DOIs
StatePublished - Mar 2021
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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