Post-translational control of endothelial nitric oxide synthase: Why isn't calcium/calmodulin enough?

David J Fulton, Jean Philippe Gratton, William C. Sessa

Research output: Contribution to journalReview article

429 Scopus citations


Endothelial nitric oxide synthase (eNOS) is important for cardiovascular homeostasis, vessel remodeling, and angiogenesis. Given the impact of endothelium- derived nitric oxide (NO) in vascular biology, much work in the past several years has focused on the control of NO synthesis by regulatory proteins that influence its function. Indeed calcium-activated calmodulin is important for regulation of NOS activity. Herein we discuss why other proteins, in addition to calmodulin, are necessary for eNOS regulation and summarize the biology of negative and positive regulators of eNOS function in vitro, in cells, and in blood vessels.

Original languageEnglish (US)
Pages (from-to)818-824
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Issue number3
Publication statusPublished - Dec 12 2001
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this