Abstract
Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na+ and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na+ handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na+ reabsorption in the kidney and the role of the epithelial Na+ channels as an important channel contributing to insulin-mediated Na+ reclamation.
Original language | English (US) |
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Pages (from-to) | F1405-F1408 |
Journal | American Journal of Physiology - Renal Physiology |
Volume | 317 |
Issue number | 6 |
DOIs | |
State | Published - 2019 |
Keywords
- Epithelial Na channel
- Fasting
- Glucose
- Insulin
ASJC Scopus subject areas
- Physiology
- Urology