Postprandial effects on electrolyte homeostasis in the kidney

Christine A. Klemens, Michael W. Brands, Alexander Staruschenko

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na+ and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na+ handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na+ reabsorption in the kidney and the role of the epithelial Na+ channels as an important channel contributing to insulin-mediated Na+ reclamation.

Original languageEnglish (US)
Pages (from-to)F1405-F1408
JournalAmerican Journal of Physiology - Renal Physiology
Volume317
Issue number6
DOIs
StatePublished - 2019

Keywords

  • Epithelial Na channel
  • Fasting
  • Glucose
  • Insulin

ASJC Scopus subject areas

  • Physiology
  • Urology

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