Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification

Graydon B. Gonsalvez, A. Gregory Matera

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter contains sections titled: Introduction Protein Methylation - Flavors and Functions Sm Proteins Contain sDMA- and aDMA-Modified Arginines SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and Spinal Muscular Atrophy (SMA) PRMT5 and PRMT7 - The Sm Protein Methyltransferases Sm Protein Methylation is Required for sn/RNP Assembly in Mammals Sm Protein Methylation in Drosophila Unresolved Questions: Sm Protein Methylation and snRNP Assembly Conclusion - The Evolution of snRNP Assembly Sm Proteins Are Required for Germ Cell Specification Dart5, Valois, Sm Proteins, and Tudor Anchoring Unresolved Questions: Sm Proteins and Germ Cell Specification The Transcriptional Functions of PRMT5 Arginine Methylation - No Longer in the Shadow of Phosphorylation Sm Proteins - Doughnut-Shaped Relics of Our RNA Past References

Original languageEnglish (US)
Title of host publicationPost-Transcriptional Gene Regulation
Subtitle of host publicationRNA Processing in Eukaryotes
PublisherWiley-Blackwell
Pages83-116
Number of pages34
ISBN (Electronic)9783527665433
ISBN (Print)9783527322022
DOIs
Publication statusPublished - Jan 1 2013

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Keywords

  • Protein methylation
  • Sm proteins
  • SnRNA
  • SnRNP
  • Spinal muscular atrophy
  • Survival motor neuron

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gonsalvez, G. B., & Gregory Matera, A. (2013). Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification. In Post-Transcriptional Gene Regulation: RNA Processing in Eukaryotes (pp. 83-116). Wiley-Blackwell. https://doi.org/10.1002/9783527665433.ch4