Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification

Graydon B. Gonsalvez, A. Gregory Matera

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter contains sections titled: Introduction Protein Methylation - Flavors and Functions Sm Proteins Contain sDMA- and aDMA-Modified Arginines SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and Spinal Muscular Atrophy (SMA) PRMT5 and PRMT7 - The Sm Protein Methyltransferases Sm Protein Methylation is Required for sn/RNP Assembly in Mammals Sm Protein Methylation in Drosophila Unresolved Questions: Sm Protein Methylation and snRNP Assembly Conclusion - The Evolution of snRNP Assembly Sm Proteins Are Required for Germ Cell Specification Dart5, Valois, Sm Proteins, and Tudor Anchoring Unresolved Questions: Sm Proteins and Germ Cell Specification The Transcriptional Functions of PRMT5 Arginine Methylation - No Longer in the Shadow of Phosphorylation Sm Proteins - Doughnut-Shaped Relics of Our RNA Past References

Original languageEnglish (US)
Title of host publicationPost-Transcriptional Gene Regulation
Subtitle of host publicationRNA Processing in Eukaryotes
Number of pages34
ISBN (Electronic)9783527665433
ISBN (Print)9783527322022
StatePublished - Jan 1 2013


  • Protein methylation
  • Sm proteins
  • SnRNA
  • SnRNP
  • Spinal muscular atrophy
  • Survival motor neuron

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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