Precipitins to an aflatoxin-producing strain of aspergillus flavus in patients with malignancy

Betty Beasley Wray, Claude A. Harmon, Elisabeth J. Rushing, Richard J. Cole

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Serum samples from 121 patients in whom malignant disease had been diagnosed, were assayed for precipitins to fungal isolates from leukemia-associated environments. Control sera were from age-, sex-, and race-matched patients with no history of malignant disease. Sera from 36 (30%) malignancy patients and seven (6%) controls yielded a precipitin band to an aflatoxin-producing Aspergillus flavus isolate from a leukemia-associated house χ2, p<0.05%). No significant numbers of precipitins were obtained to either of the other fungal isolates from that and another such house. Although A. fumigatus has frequently been incriminated as a source of infection in patients with malignancy, only 9% of malignancy patients had a precipitin response to it, as did 1.6% of controls. Also, the presence of the precipitins to A. flavus was not connected with past radiation or imunosuppressive therapy. However, among patients with precipitins to A. fumigatus there was a higher death rate in the year following the study. Precipitins to A. flavus may be related to heavy environmental exposure possibly leading to aflatoxin exposure which may contribute to development of malignancy through immunosuppressive effects.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalJournal of Cancer Research and Clinical Oncology
Volume103
Issue number2
DOIs
StatePublished - May 1 1982
Externally publishedYes

Fingerprint

Aspergillus flavus
Precipitins
Aflatoxins
Neoplasms
Leukemia
Serum
Environmental Exposure
Immunosuppressive Agents
Radiation
Mortality
Infection

Keywords

  • Aspergillus
  • Malignancy
  • Precipitins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Precipitins to an aflatoxin-producing strain of aspergillus flavus in patients with malignancy. / Wray, Betty Beasley; Harmon, Claude A.; Rushing, Elisabeth J.; Cole, Richard J.

In: Journal of Cancer Research and Clinical Oncology, Vol. 103, No. 2, 01.05.1982, p. 181-185.

Research output: Contribution to journalArticle

Wray, Betty Beasley ; Harmon, Claude A. ; Rushing, Elisabeth J. ; Cole, Richard J. / Precipitins to an aflatoxin-producing strain of aspergillus flavus in patients with malignancy. In: Journal of Cancer Research and Clinical Oncology. 1982 ; Vol. 103, No. 2. pp. 181-185.
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