Preconditioning and stem cell survival

Husnain Kh Haider, Muhammad Ashraf

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

The harsh ischemic and cytokine-rich microenvironment in the infarcted myocardium, infiltrated by the inflammatory and immune cells, offers a significant challenge to the transplanted donor stem cells. Massive cell death occurs during transplantation as well as following engraftment which significantly lowers the effectiveness of the heart cell therapy. Various approaches have been adopted to overcome this problem nevertheless with multiple limitations with each of these current approaches. Cellular preconditioning and reprogramming by physical, chemical, genetic, and pharmacological manipulation of the cells has shown promise and "prime" the cells to the "state of readiness" to withstand the rigors of lethal ischemia in vitro as well as posttransplantation. This review summarizes the past and present novel approaches of ischemic preconditioning, pharmacological and genetic manipulation using preconditioning mimetics, recombinant growth factor protein treatment, and reprogramming of stem cells to overexpress survival signaling molecules, microRNAs, and trophic factors for intracrine, autocrine, and paracrine effects on cytoprotection

Original languageEnglish (US)
Pages (from-to)89-102
Number of pages14
JournalJournal of Cardiovascular Translational Research
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2010

Fingerprint

Cell Survival
Stem Cells
Pharmacology
Ischemic Preconditioning
Cytoprotection
Cell- and Tissue-Based Therapy
MicroRNAs
Intercellular Signaling Peptides and Proteins
Myocardium
Cell Death
Ischemia
Transplantation
Cytokines
Proteins
Therapeutics
Cellular Reprogramming
In Vitro Techniques

Keywords

  • Ischemia
  • Myocardial infarction
  • Preconditioning
  • Stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

Preconditioning and stem cell survival. / Haider, Husnain Kh; Ashraf, Muhammad.

In: Journal of Cardiovascular Translational Research, Vol. 3, No. 2, 01.04.2010, p. 89-102.

Research output: Contribution to journalReview article

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