Predicting asthma severity from allergic sensitivity to cockroaches in pregnant inner city women

Cassandra E. Henderson, Dennis Randall Ownby, Ann Trumble, Rebecca DerSimonian, Leonard H. Kellner

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: To measure and compare cockroach (CR)-specific immunoglobin E (IgE) in sera from pregnant women with mild, moderate and severe asthma. STUDY DESIGN: CR IgE levels were measured in stored sera collected during the Collaborative Perinatal Project. Three matched groups of 93 women were formed: group I (mild), history of asthma but no acute exacerbation; group II (moderate), acute asthma exacerbation; group III (severe), required hospitalization for a diagnosis of status asthmaticus. ANOVA was used to compare the three means. RESULTS: Mean CR IgE paralleled prenatal asthma severity. Mean values were 6.50, 13.12 and 28.99 kU/L for groups I, II and III, respectively (P = .06). High allergen sensitivity, defined as CR IgE > 60 kU/L, was identified in 8 of the 93 study samples. The prevalence of high allergen sensitivity increased as clinical asthma became more severe. Sixty- two percent (5/8) of the high allergen sensitivity occurred in group III. CONCLUSION: There appears to be a positive correlation between sensitivity to CR allergens and asthma severity during pregnancy, and these findings support further evaluation of CR allergen sensitivity as a predictor of asthma severity in pregnancy.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume45
Issue number4
StatePublished - May 15 2000

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Cockroaches
Asthma
Allergens
Status Asthmaticus
Pregnancy
Serum
Pregnant Women
Analysis of Variance
Hospitalization
Research Design

Keywords

  • Asthma
  • Cockroaches
  • IgE
  • Pregnancy complications

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Predicting asthma severity from allergic sensitivity to cockroaches in pregnant inner city women. / Henderson, Cassandra E.; Ownby, Dennis Randall; Trumble, Ann; DerSimonian, Rebecca; Kellner, Leonard H.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 45, No. 4, 15.05.2000, p. 341-344.

Research output: Contribution to journalArticle

Henderson, Cassandra E. ; Ownby, Dennis Randall ; Trumble, Ann ; DerSimonian, Rebecca ; Kellner, Leonard H. / Predicting asthma severity from allergic sensitivity to cockroaches in pregnant inner city women. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2000 ; Vol. 45, No. 4. pp. 341-344.
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