Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome

David A. Ehrmann, David R. Liljenquist, Kristen Kasza, Ricardo Azziz, Richard S. Legro, Mahmoud N. Ghazzi, Stephen Aronoff, Richard Bernstein, Donald Bodenner, Susan Braithwaite, Joshua Cohen, David DePaolo, Daniel Einhorn, Jennifer Hone, Anne Kenshole, Charles Kilo, Siri Linda Kjos, Mary Korytkowski, Diane Koster, Rebecca Lau & 13 others Rogerio Lobo, Jean Lucas, Kathryn Martin, William Meyer, Sumer Pek, Samantha Pfeifer, Robert Rebar, Geoffrey Redmond, Roger Rittmaster, Peter Ross, Sherwyn Schwartz, Robert Wild, Samuel S.C. Yen

Research output: Contribution to journalArticle

437 Citations (Scopus)

Abstract

Context: Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis. Objective: This study was performed to determine the prevalence and predictors of the metabolic syndrome in PCOS. Design: The clinical, hormonal, and oral glucose tolerance test results were analyzed in 394 PCOS women who were screened for participation in a multicenter trial to evaluate the effects of troglitazone on ovulation and hirsutism. Setting: A multicenter clinical trial is presented. Patients or Other Participants: The subjects were women with PCOS who had or lacked the metabolic syndrome. Main Outcome Measures: Waist circumference, fasting glucose, high-density lipoprotein cholesterol and triglyceride concentrations, and blood pressure were the main outcome measures. Results: Twenty-six (6.6%) subjects had diabetes; among the 368 nondiabetics, the prevalence for individual components comprising the metabolic syndrome were: waist circumference greater than 88 cm in 80%, high-density lipoprotein cholesterol less than 50 mg/dl in 66%, triglycerides greater than or equal to 150 mg/dl in 32%, blood pressure greater than or equal to 130/85 mm Hg in 21%, and fasting glucose concentrations greater than or equal to 110 mg/dl in 5%. Three or more of these individual criteria were present in 123 (33.4%) subjects overall. The prevalence of the metabolic syndrome did not differ significantly between racial/ethnic groups. The prevalence of the metabolic syndrome from lowest to highest quartile of free testosterone concentration was 19.8, 31.3, 46.9, and 35.0%, respectively [P = 0.056 adjusted for body mass index (BMI)]. None of the 52 women with a BMI less than 27.0 kg/m2 had the metabolic syndrome; those in the top BMI quartile were 13.7 times more likely (95% confidence interval, 5.7-33.0) to have the metabolic syndrome compared with those in the lowest quartile. Thirty-eight percent of those with the metabolic syndrome had impaired glucose tolerance compared with 19% without the metabolic syndrome (P < 0.001). Conclusions: The metabolic syndrome and its individual components are common in PCOS, particularly among women with the highest insulin levels and BMI. Hyperinsulinemia is a likely common pathogenetic factor for both PCOS and the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Polycystic Ovary Syndrome
Glucose
Blood pressure
troglitazone
HDL Cholesterol
Body Mass Index
Medical problems
Testosterone
Triglycerides
Waist Circumference
Insulin
Multicenter Studies
Fasting
Outcome Assessment (Health Care)
Blood Pressure
Hirsutism
Glucose Intolerance
Hyperinsulinism
Glucose Tolerance Test
Ovulation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., Ghazzi, M. N., ... Yen, S. S. C. (2006). Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 91(1), 48-53. https://doi.org/10.1210/jc.2005-1329

Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. / Ehrmann, David A.; Liljenquist, David R.; Kasza, Kristen; Azziz, Ricardo; Legro, Richard S.; Ghazzi, Mahmoud N.; Aronoff, Stephen; Bernstein, Richard; Bodenner, Donald; Braithwaite, Susan; Cohen, Joshua; DePaolo, David; Einhorn, Daniel; Hone, Jennifer; Kenshole, Anne; Kilo, Charles; Kjos, Siri Linda; Korytkowski, Mary; Koster, Diane; Lau, Rebecca; Lobo, Rogerio; Lucas, Jean; Martin, Kathryn; Meyer, William; Pek, Sumer; Pfeifer, Samantha; Rebar, Robert; Redmond, Geoffrey; Rittmaster, Roger; Ross, Peter; Schwartz, Sherwyn; Wild, Robert; Yen, Samuel S.C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 1, 01.01.2006, p. 48-53.

Research output: Contribution to journalArticle

Ehrmann, DA, Liljenquist, DR, Kasza, K, Azziz, R, Legro, RS, Ghazzi, MN, Aronoff, S, Bernstein, R, Bodenner, D, Braithwaite, S, Cohen, J, DePaolo, D, Einhorn, D, Hone, J, Kenshole, A, Kilo, C, Kjos, SL, Korytkowski, M, Koster, D, Lau, R, Lobo, R, Lucas, J, Martin, K, Meyer, W, Pek, S, Pfeifer, S, Rebar, R, Redmond, G, Rittmaster, R, Ross, P, Schwartz, S, Wild, R & Yen, SSC 2006, 'Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 1, pp. 48-53. https://doi.org/10.1210/jc.2005-1329
Ehrmann, David A. ; Liljenquist, David R. ; Kasza, Kristen ; Azziz, Ricardo ; Legro, Richard S. ; Ghazzi, Mahmoud N. ; Aronoff, Stephen ; Bernstein, Richard ; Bodenner, Donald ; Braithwaite, Susan ; Cohen, Joshua ; DePaolo, David ; Einhorn, Daniel ; Hone, Jennifer ; Kenshole, Anne ; Kilo, Charles ; Kjos, Siri Linda ; Korytkowski, Mary ; Koster, Diane ; Lau, Rebecca ; Lobo, Rogerio ; Lucas, Jean ; Martin, Kathryn ; Meyer, William ; Pek, Sumer ; Pfeifer, Samantha ; Rebar, Robert ; Redmond, Geoffrey ; Rittmaster, Roger ; Ross, Peter ; Schwartz, Sherwyn ; Wild, Robert ; Yen, Samuel S.C. / Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 1. pp. 48-53.
@article{9e616b1d574a492eb75c65d8fe2e50f2,
title = "Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome",
abstract = "Context: Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis. Objective: This study was performed to determine the prevalence and predictors of the metabolic syndrome in PCOS. Design: The clinical, hormonal, and oral glucose tolerance test results were analyzed in 394 PCOS women who were screened for participation in a multicenter trial to evaluate the effects of troglitazone on ovulation and hirsutism. Setting: A multicenter clinical trial is presented. Patients or Other Participants: The subjects were women with PCOS who had or lacked the metabolic syndrome. Main Outcome Measures: Waist circumference, fasting glucose, high-density lipoprotein cholesterol and triglyceride concentrations, and blood pressure were the main outcome measures. Results: Twenty-six (6.6{\%}) subjects had diabetes; among the 368 nondiabetics, the prevalence for individual components comprising the metabolic syndrome were: waist circumference greater than 88 cm in 80{\%}, high-density lipoprotein cholesterol less than 50 mg/dl in 66{\%}, triglycerides greater than or equal to 150 mg/dl in 32{\%}, blood pressure greater than or equal to 130/85 mm Hg in 21{\%}, and fasting glucose concentrations greater than or equal to 110 mg/dl in 5{\%}. Three or more of these individual criteria were present in 123 (33.4{\%}) subjects overall. The prevalence of the metabolic syndrome did not differ significantly between racial/ethnic groups. The prevalence of the metabolic syndrome from lowest to highest quartile of free testosterone concentration was 19.8, 31.3, 46.9, and 35.0{\%}, respectively [P = 0.056 adjusted for body mass index (BMI)]. None of the 52 women with a BMI less than 27.0 kg/m2 had the metabolic syndrome; those in the top BMI quartile were 13.7 times more likely (95{\%} confidence interval, 5.7-33.0) to have the metabolic syndrome compared with those in the lowest quartile. Thirty-eight percent of those with the metabolic syndrome had impaired glucose tolerance compared with 19{\%} without the metabolic syndrome (P < 0.001). Conclusions: The metabolic syndrome and its individual components are common in PCOS, particularly among women with the highest insulin levels and BMI. Hyperinsulinemia is a likely common pathogenetic factor for both PCOS and the metabolic syndrome.",
author = "Ehrmann, {David A.} and Liljenquist, {David R.} and Kristen Kasza and Ricardo Azziz and Legro, {Richard S.} and Ghazzi, {Mahmoud N.} and Stephen Aronoff and Richard Bernstein and Donald Bodenner and Susan Braithwaite and Joshua Cohen and David DePaolo and Daniel Einhorn and Jennifer Hone and Anne Kenshole and Charles Kilo and Kjos, {Siri Linda} and Mary Korytkowski and Diane Koster and Rebecca Lau and Rogerio Lobo and Jean Lucas and Kathryn Martin and William Meyer and Sumer Pek and Samantha Pfeifer and Robert Rebar and Geoffrey Redmond and Roger Rittmaster and Peter Ross and Sherwyn Schwartz and Robert Wild and Yen, {Samuel S.C.}",
year = "2006",
month = "1",
day = "1",
doi = "10.1210/jc.2005-1329",
language = "English (US)",
volume = "91",
pages = "48--53",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome

AU - Ehrmann, David A.

AU - Liljenquist, David R.

AU - Kasza, Kristen

AU - Azziz, Ricardo

AU - Legro, Richard S.

AU - Ghazzi, Mahmoud N.

AU - Aronoff, Stephen

AU - Bernstein, Richard

AU - Bodenner, Donald

AU - Braithwaite, Susan

AU - Cohen, Joshua

AU - DePaolo, David

AU - Einhorn, Daniel

AU - Hone, Jennifer

AU - Kenshole, Anne

AU - Kilo, Charles

AU - Kjos, Siri Linda

AU - Korytkowski, Mary

AU - Koster, Diane

AU - Lau, Rebecca

AU - Lobo, Rogerio

AU - Lucas, Jean

AU - Martin, Kathryn

AU - Meyer, William

AU - Pek, Sumer

AU - Pfeifer, Samantha

AU - Rebar, Robert

AU - Redmond, Geoffrey

AU - Rittmaster, Roger

AU - Ross, Peter

AU - Schwartz, Sherwyn

AU - Wild, Robert

AU - Yen, Samuel S.C.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Context: Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis. Objective: This study was performed to determine the prevalence and predictors of the metabolic syndrome in PCOS. Design: The clinical, hormonal, and oral glucose tolerance test results were analyzed in 394 PCOS women who were screened for participation in a multicenter trial to evaluate the effects of troglitazone on ovulation and hirsutism. Setting: A multicenter clinical trial is presented. Patients or Other Participants: The subjects were women with PCOS who had or lacked the metabolic syndrome. Main Outcome Measures: Waist circumference, fasting glucose, high-density lipoprotein cholesterol and triglyceride concentrations, and blood pressure were the main outcome measures. Results: Twenty-six (6.6%) subjects had diabetes; among the 368 nondiabetics, the prevalence for individual components comprising the metabolic syndrome were: waist circumference greater than 88 cm in 80%, high-density lipoprotein cholesterol less than 50 mg/dl in 66%, triglycerides greater than or equal to 150 mg/dl in 32%, blood pressure greater than or equal to 130/85 mm Hg in 21%, and fasting glucose concentrations greater than or equal to 110 mg/dl in 5%. Three or more of these individual criteria were present in 123 (33.4%) subjects overall. The prevalence of the metabolic syndrome did not differ significantly between racial/ethnic groups. The prevalence of the metabolic syndrome from lowest to highest quartile of free testosterone concentration was 19.8, 31.3, 46.9, and 35.0%, respectively [P = 0.056 adjusted for body mass index (BMI)]. None of the 52 women with a BMI less than 27.0 kg/m2 had the metabolic syndrome; those in the top BMI quartile were 13.7 times more likely (95% confidence interval, 5.7-33.0) to have the metabolic syndrome compared with those in the lowest quartile. Thirty-eight percent of those with the metabolic syndrome had impaired glucose tolerance compared with 19% without the metabolic syndrome (P < 0.001). Conclusions: The metabolic syndrome and its individual components are common in PCOS, particularly among women with the highest insulin levels and BMI. Hyperinsulinemia is a likely common pathogenetic factor for both PCOS and the metabolic syndrome.

AB - Context: Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis. Objective: This study was performed to determine the prevalence and predictors of the metabolic syndrome in PCOS. Design: The clinical, hormonal, and oral glucose tolerance test results were analyzed in 394 PCOS women who were screened for participation in a multicenter trial to evaluate the effects of troglitazone on ovulation and hirsutism. Setting: A multicenter clinical trial is presented. Patients or Other Participants: The subjects were women with PCOS who had or lacked the metabolic syndrome. Main Outcome Measures: Waist circumference, fasting glucose, high-density lipoprotein cholesterol and triglyceride concentrations, and blood pressure were the main outcome measures. Results: Twenty-six (6.6%) subjects had diabetes; among the 368 nondiabetics, the prevalence for individual components comprising the metabolic syndrome were: waist circumference greater than 88 cm in 80%, high-density lipoprotein cholesterol less than 50 mg/dl in 66%, triglycerides greater than or equal to 150 mg/dl in 32%, blood pressure greater than or equal to 130/85 mm Hg in 21%, and fasting glucose concentrations greater than or equal to 110 mg/dl in 5%. Three or more of these individual criteria were present in 123 (33.4%) subjects overall. The prevalence of the metabolic syndrome did not differ significantly between racial/ethnic groups. The prevalence of the metabolic syndrome from lowest to highest quartile of free testosterone concentration was 19.8, 31.3, 46.9, and 35.0%, respectively [P = 0.056 adjusted for body mass index (BMI)]. None of the 52 women with a BMI less than 27.0 kg/m2 had the metabolic syndrome; those in the top BMI quartile were 13.7 times more likely (95% confidence interval, 5.7-33.0) to have the metabolic syndrome compared with those in the lowest quartile. Thirty-eight percent of those with the metabolic syndrome had impaired glucose tolerance compared with 19% without the metabolic syndrome (P < 0.001). Conclusions: The metabolic syndrome and its individual components are common in PCOS, particularly among women with the highest insulin levels and BMI. Hyperinsulinemia is a likely common pathogenetic factor for both PCOS and the metabolic syndrome.

UR - http://www.scopus.com/inward/record.url?scp=30344448576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30344448576&partnerID=8YFLogxK

U2 - 10.1210/jc.2005-1329

DO - 10.1210/jc.2005-1329

M3 - Article

VL - 91

SP - 48

EP - 53

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 1

ER -