Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomas

Marina N. Nikiforova, Christy M. Caudill, Paul Biddinger, Yuri E. Nikiforov

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thyroid cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC rearrangements in histologically benign tissue affected by HT, suggesting that multiple occult tumors exist in HT patients with high frequency. We tested the prevalence of RET/PTC rearrangements in 26 HT, in 6 papillary carcinomas arising in the background of HT, and in 27 papillary carcinomas not associated with HT. We detected no RET/PTC rearrangements in HT or papillary carcinomas arising in the background of HT, in contrast to a 33% prevalence among papillary carcinomas not associated with HT. However, the expression of wild-type RET was found in more than half of papillary carcinomas. These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalInternational Journal of Surgical Pathology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Hashimito's thyroiditis
  • Papillary carcinoma
  • RET gene
  • RET/PTC rearrangement
  • Thyroid

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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