Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist

Gennady N. Smagin, Leigh Anne Howell, Stephen Redmann, Donna H. Ryan, Ruth B.S. Harris

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

We previously reported that rats exposed to repeated restraint (3 h/day for 3 days) experience temporary hypophagia and a sustained reduction in body weight compared with nonrestrained controls. Studies described here determined the involvement of central corticotropin-releasing factor (CRF) receptors in the initiation of this chronic response to acute stress. In experiment 1, Sprague-Dawley rats were fitted with cannulas in the lateral ventricle and infused with 50 μg of αhCRF-(9-41) or saline immediately before restraint on each of the 3 days of restraint. The receptor antagonist inhibited hypophagia and weight loss on day 1 of restraint but not on days 2 and 3. In experiment 2, 10 μg of αhCRF-(941) or saline were infused into the third ventricle immediately before each restraint. The receptor antagonist totally blocked stress-induced hypophagia and weight loss. These results demonstrate that CRF receptors located in or near the hypothalamus mediate the acute responses to stress that lead to a permanent change in the hormonal or metabolic processes that determine body weight and body composition.

Original languageEnglish (US)
Pages (from-to)R1461-R1468
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume276
Issue number5 45-5
DOIs
StatePublished - May 1999
Externally publishedYes

Keywords

  • Food intake
  • Restraint stress
  • αhCRF-(9-41)

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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