Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Shogo Mori, Keshav K. Nepal, Gilbert T. Kelly, Vasudha Sharma, Dinesh Simkhada, Vishruth Gowda, Dioscar Delgado, Coran M.H. Watanabe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

Original languageEnglish (US)
Pages (from-to)805-808
Number of pages4
JournalBiochemistry
Volume56
Issue number6
DOIs
StatePublished - Feb 14 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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