Abstract
The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.
Original language | English (US) |
---|---|
Pages (from-to) | 805-808 |
Number of pages | 4 |
Journal | Biochemistry |
Volume | 56 |
Issue number | 6 |
DOIs | |
State | Published - Feb 14 2017 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry