PRKCD/PKCδ contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy

Dongshan Zhang, Xuan Xu, Zheng Dong

Research output: Contribution to journalComment/debate

12 Scopus citations

Abstract

Nephrotoxicity is a major side effect during chemotherapy with cisplatin and related platinum compounds. Previous work unveiled a role of PRKCD/PKCδ (protein kinase C delta) in cisplatin-induced nephrotoxicity; however, the underlying mechanism was largely unknown. Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.

Original languageEnglish (US)
Pages (from-to)631-632
Number of pages2
JournalAutophagy
Volume13
Issue number3
DOIs
StatePublished - Mar 4 2017

Keywords

  • AKT
  • MTOR
  • PKCδ
  • autophagy
  • chemotherapy
  • cisplatin
  • kidney
  • nephrotoxicity
  • side effect

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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