PRKCD/PKCδ contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy

Dongshan Zhang, Xuan Xu, Zheng Dong

Research output: Contribution to journalComment/debate

9 Citations (Scopus)

Abstract

Nephrotoxicity is a major side effect during chemotherapy with cisplatin and related platinum compounds. Previous work unveiled a role of PRKCD/PKCδ (protein kinase C delta) in cisplatin-induced nephrotoxicity; however, the underlying mechanism was largely unknown. Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.

Original languageEnglish (US)
Pages (from-to)631-632
Number of pages2
JournalAutophagy
Volume13
Issue number3
DOIs
StatePublished - Mar 4 2017

Fingerprint

Autophagy
Cisplatin
Drug Therapy
Protein Kinase C-delta
Platinum Compounds
Kidney Tubules
Cell Death
Therapeutics

Keywords

  • AKT
  • MTOR
  • PKCδ
  • autophagy
  • chemotherapy
  • cisplatin
  • kidney
  • nephrotoxicity
  • side effect

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

PRKCD/PKCδ contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy. / Zhang, Dongshan; Xu, Xuan; Dong, Zheng.

In: Autophagy, Vol. 13, No. 3, 04.03.2017, p. 631-632.

Research output: Contribution to journalComment/debate

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