Prognostic factors and risk assessment in chronic myelomonocytic leukemia: Validation study of the M.D. Anderson Prognostic Scoring System

Miloslav Beran, Sijin Wen, Yu Shen, Francesco Onida, Jaroslav Jelinek, Jorge Cortes, Francis Giles, Hagop Kantarjian

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Chronic myelomonocytic leukemia continues to be a poorly understood disease, defined by clinical rather than biological features, with no consensus on optimal therapy. In the past, patients were often assessed for risk using scoring systems developed for other diseases, notably the International Prognostic Scoring System commonly used for myelodysplastic syndrome. The M.D. Anderson Prognostic Scoring System, using hemoglobin, absolute lymphocyte count, peripheral blood immature cells, and bone marrow blasts, was developed specifically for CMML; it was based on retrospective analysis of 213 patients. This report re-examines the validity of this scoring system based on follow-up of the initial cohort and prospectively examines its validity in 250 new patients. Both the original MDAPS system and a modified version derived from data of the initial cohort after extended follow-up (substituting lactate dehydrogenase for bone marrow blasts) effectively stratify both patient cohorts by survival and provide a useful risk assessment tool and additional guidance during treatment decisions.

Original languageEnglish (US)
Pages (from-to)1150-1160
Number of pages11
JournalLeukemia and Lymphoma
Volume48
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Chronic myelomonocytic leukemia
  • Risk assessment
  • Scoring system

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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