Prognostic factors associated with disease progression and overall survival in patients with myelodysplastic syndromes treated with decitabine

Elias Jabbour; Guillermo Garcia-Manero; Farhad Ravandi; Stefan Faderl; Susan O'Brien; Amber Fullmer; Jorge E. Cortes; William Wierda; Hagop Kantarjian

doi:10.1016/j.clml.2012.11.001

Prognostic factors associated with disease progression and overall survival in patients with myelodysplastic syndromes treated with decitabine

Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi, Stefan Faderl, Susan O'Brien, Amber Fullmer, Jorge E. Cortes, William Wierda, Hagop Kantarjian

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: Myelodysplastic syndromes (MDS) progress to acute myeloid leukemia (AML) in approximately 30% of patients. Identification of risk factors for progression to AML and overall survival (OS) would help guide treatment decisions. Patients and Methods: We investigated prognostic factors for progression to AML and survival in 163 patients with MDS treated with decitabine 15 mg/m² over 3 hours every 8 hours for 3 days every 6 weeks (n = 74) or 20 mg/m² over 1 hour daily for 5 days every 4 weeks (n = 89). Results: Multivariate analysis of pooled baseline data revealed that only study effect was associated with progression to AML. A hemoglobin value at least 10 g/dL, platelet count at least 50 × 10³/μL, and lack of chromosome 5 or 7 abnormalities were associated with longer OS. Conclusions: Patients with certain prognostic factors should be considered for other interventions in addition to decitabine treatment.

Original language	English (US)
Pages (from-to)	131-138
Number of pages	8
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.clml.2012.11.001
State	Published - Apr 2013
Externally published	Yes

Keywords

Acute myeloid leukemia
Decitabine
Myelodysplastic syndromes
Myelomonocytic leukemia
Risk factors
chronic

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Jabbour, E., Garcia-Manero, G., Ravandi, F., Faderl, S., O'Brien, S., Fullmer, A., Cortes, J. E., Wierda, W., & Kantarjian, H. (2013). Prognostic factors associated with disease progression and overall survival in patients with myelodysplastic syndromes treated with decitabine. Clinical Lymphoma, Myeloma and Leukemia, 13(2), 131-138. https://doi.org/10.1016/j.clml.2012.11.001

Prognostic factors associated with disease progression and overall survival in patients with myelodysplastic syndromes treated with decitabine. / Jabbour, Elias; Garcia-Manero, Guillermo; Ravandi, Farhad; Faderl, Stefan; O'Brien, Susan; Fullmer, Amber; Cortes, Jorge E.; Wierda, William; Kantarjian, Hagop.

In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 13, No. 2, 04.2013, p. 131-138.

Research output: Contribution to journal › Article › peer-review

Jabbour, E, Garcia-Manero, G, Ravandi, F, Faderl, S, O'Brien, S, Fullmer, A, Cortes, JE, Wierda, W & Kantarjian, H 2013, 'Prognostic factors associated with disease progression and overall survival in patients with myelodysplastic syndromes treated with decitabine', Clinical Lymphoma, Myeloma and Leukemia, vol. 13, no. 2, pp. 131-138. https://doi.org/10.1016/j.clml.2012.11.001

Jabbour, Elias ; Garcia-Manero, Guillermo ; Ravandi, Farhad ; Faderl, Stefan ; O'Brien, Susan ; Fullmer, Amber ; Cortes, Jorge E. ; Wierda, William ; Kantarjian, Hagop. / Prognostic factors associated with disease progression and overall survival in patients with myelodysplastic syndromes treated with decitabine. In: Clinical Lymphoma, Myeloma and Leukemia. 2013 ; Vol. 13, No. 2. pp. 131-138.

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abstract = "Background: Myelodysplastic syndromes (MDS) progress to acute myeloid leukemia (AML) in approximately 30% of patients. Identification of risk factors for progression to AML and overall survival (OS) would help guide treatment decisions. Patients and Methods: We investigated prognostic factors for progression to AML and survival in 163 patients with MDS treated with decitabine 15 mg/m2 over 3 hours every 8 hours for 3 days every 6 weeks (n = 74) or 20 mg/m2 over 1 hour daily for 5 days every 4 weeks (n = 89). Results: Multivariate analysis of pooled baseline data revealed that only study effect was associated with progression to AML. A hemoglobin value at least 10 g/dL, platelet count at least 50 × 103/μL, and lack of chromosome 5 or 7 abnormalities were associated with longer OS. Conclusions: Patients with certain prognostic factors should be considered for other interventions in addition to decitabine treatment.",

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AU - O'Brien, Susan

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AB - Background: Myelodysplastic syndromes (MDS) progress to acute myeloid leukemia (AML) in approximately 30% of patients. Identification of risk factors for progression to AML and overall survival (OS) would help guide treatment decisions. Patients and Methods: We investigated prognostic factors for progression to AML and survival in 163 patients with MDS treated with decitabine 15 mg/m2 over 3 hours every 8 hours for 3 days every 6 weeks (n = 74) or 20 mg/m2 over 1 hour daily for 5 days every 4 weeks (n = 89). Results: Multivariate analysis of pooled baseline data revealed that only study effect was associated with progression to AML. A hemoglobin value at least 10 g/dL, platelet count at least 50 × 103/μL, and lack of chromosome 5 or 7 abnormalities were associated with longer OS. Conclusions: Patients with certain prognostic factors should be considered for other interventions in addition to decitabine treatment.

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