Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer

Paul Maurice Weinberger, Z. Yu, B. G. Haffty, D. Kowalski, M. Harigopal, C. Sasaki, D. L. Rimm, Amanda Psyrri

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Purpose: Functional inactivation of p16 is an early and frequent event in head and neck squamous cell cancers. In this study, we sought to determine whether p16 expression is of prognostic importance in oropharyngeal squamous cell carcinoma. Experimental Design: p16 protein expression was evaluated by immunohistochemistry in a tissue microarray composed of 123 oropharyngeal squamous cell cancers with a mean patient follow-up time of 33 months. Results: p16 overexpression was associated with more advanced Tumor-Node-Metastasis stage and higher histologic grade. Despite this association with unfavorable features, p16 overexpression was associated with decreased 5-year local recurrence rates (11 versus 53%) and increased 5-year disease-free survival (62 versus 19%) and overall survival (60 versus 21%). In multivariate analysis, p16 expression status remained an independent prognostic factor for local recurrence, disease-free survival, and overall survival. Conclusions: In patients with oropharyngeal squamous cell carcinoma, overexpression of p16 as determined by immunohistochemistry is associated with significantly improved prognosis and lower local recurrence rates.

Original languageEnglish (US)
Pages (from-to)5684-5691
Number of pages8
JournalClinical Cancer Research
Volume10
Issue number17
DOIs
StatePublished - Sep 1 2004

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Oropharyngeal Neoplasms
Squamous Cell Neoplasms
Recurrence
Disease-Free Survival
Squamous Cell Carcinoma
Immunohistochemistry
Proteins
Survival
Head and Neck Neoplasms
Research Design
Multivariate Analysis
Head
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Weinberger, P. M., Yu, Z., Haffty, B. G., Kowalski, D., Harigopal, M., Sasaki, C., ... Psyrri, A. (2004). Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clinical Cancer Research, 10(17), 5684-5691. https://doi.org/10.1158/1078-0432.CCR-04-0448

Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. / Weinberger, Paul Maurice; Yu, Z.; Haffty, B. G.; Kowalski, D.; Harigopal, M.; Sasaki, C.; Rimm, D. L.; Psyrri, Amanda.

In: Clinical Cancer Research, Vol. 10, No. 17, 01.09.2004, p. 5684-5691.

Research output: Contribution to journalArticle

Weinberger, PM, Yu, Z, Haffty, BG, Kowalski, D, Harigopal, M, Sasaki, C, Rimm, DL & Psyrri, A 2004, 'Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer', Clinical Cancer Research, vol. 10, no. 17, pp. 5684-5691. https://doi.org/10.1158/1078-0432.CCR-04-0448
Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Sasaki C et al. Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clinical Cancer Research. 2004 Sep 1;10(17):5684-5691. https://doi.org/10.1158/1078-0432.CCR-04-0448
Weinberger, Paul Maurice ; Yu, Z. ; Haffty, B. G. ; Kowalski, D. ; Harigopal, M. ; Sasaki, C. ; Rimm, D. L. ; Psyrri, Amanda. / Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. In: Clinical Cancer Research. 2004 ; Vol. 10, No. 17. pp. 5684-5691.
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AB - Purpose: Functional inactivation of p16 is an early and frequent event in head and neck squamous cell cancers. In this study, we sought to determine whether p16 expression is of prognostic importance in oropharyngeal squamous cell carcinoma. Experimental Design: p16 protein expression was evaluated by immunohistochemistry in a tissue microarray composed of 123 oropharyngeal squamous cell cancers with a mean patient follow-up time of 33 months. Results: p16 overexpression was associated with more advanced Tumor-Node-Metastasis stage and higher histologic grade. Despite this association with unfavorable features, p16 overexpression was associated with decreased 5-year local recurrence rates (11 versus 53%) and increased 5-year disease-free survival (62 versus 19%) and overall survival (60 versus 21%). In multivariate analysis, p16 expression status remained an independent prognostic factor for local recurrence, disease-free survival, and overall survival. Conclusions: In patients with oropharyngeal squamous cell carcinoma, overexpression of p16 as determined by immunohistochemistry is associated with significantly improved prognosis and lower local recurrence rates.

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