Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia

Srdan Verstovsek, Hagop Kantarjian, Taghi Manshouri, Susan O'Brien, Stefan Faderl, Moshe Talpaz, Jorge Cortes, Maher Albitar

Research output: Contribution to journalArticle

Abstract

BACKGROUND. The Tie-1 tyrosine kinase receptor and its thus far unidentified ligand appear to play a distinct role in the regulatory pathways of early hematopoiesis and angiogenesis. Because vascularity is increased in the bone marrow of patients with chronic myeloid leukemia (CML), the authors evaluated the clinical significance of Tie-1 expression in such patients. METHODS. Using Western blot analysis and solid-phase radioimmunoassay (RIA), the authors quantified Tie-1 protein in bone marrow samples from 128 patients with CML and 31 normal controls. RESULTS. The median Tie-1 RIA value of CML samples was significantly higher than in normal controls (P = 0.01). The authors found no significant differences in Tie-1 levels in patients with early chronic, late chronic, accelerated, and blastic phases (P = 0.2). High Tie-1 levels correlated with short survival in patients with early chronic phase (P = 0.003; Cox proportional hazard model) but not in patients with late chronic (P = 0.2) or accelerated/blastic (P = 0.2) phase CML. Tie-1 protein level was also prognostic when patients were separated into two groups by the median value. High Tie-1 level in early chronic phase was associated with significantly shorter survival than low Tie-1 level (median survival, 116 vs. 61 months; P = 0.03). In patients with early chronic phase CML, Tie-1 levels correlated directly with patient age (P = 0.004) and platelet count (P = 0.003), and inversely with leukocyte count (P = 0.007). Tie-1 as a predictor of survival in early chronic phase CML was independent of risk group, spleen size, age, hemoglobin, and basophil count (P = 0.03; multivariate Cox proportional hazard model). CONCLUSI0NS. The authors' findings support the hypothesis that angiogenesis may play a major role in the pathophysiology of chronic phase CML.

Original languageEnglish (US)
Pages (from-to)1517-1521
Number of pages5
JournalCancer
Volume94
Issue number5
DOIs
StatePublished - Mar 1 2002
Externally publishedYes

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Leukemia, Myeloid, Chronic Phase
Proteins
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Survival
Proportional Hazards Models
Radioimmunoassay
Bone Marrow
Basophils
Hematopoiesis
Receptor Protein-Tyrosine Kinases
Platelet Count
Leukocyte Count
Hemoglobins
Spleen
Western Blotting
Ligands

Keywords

  • Angiogenesis
  • Bone marrow
  • Chronic myeloid leukemia
  • Expression
  • Prognostic factor
  • Tie-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Verstovsek, S., Kantarjian, H., Manshouri, T., O'Brien, S., Faderl, S., Talpaz, M., ... Albitar, M. (2002). Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. Cancer, 94(5), 1517-1521. https://doi.org/10.1002/cncr.10363

Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. / Verstovsek, Srdan; Kantarjian, Hagop; Manshouri, Taghi; O'Brien, Susan; Faderl, Stefan; Talpaz, Moshe; Cortes, Jorge; Albitar, Maher.

In: Cancer, Vol. 94, No. 5, 01.03.2002, p. 1517-1521.

Research output: Contribution to journalArticle

Verstovsek, S, Kantarjian, H, Manshouri, T, O'Brien, S, Faderl, S, Talpaz, M, Cortes, J & Albitar, M 2002, 'Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia', Cancer, vol. 94, no. 5, pp. 1517-1521. https://doi.org/10.1002/cncr.10363
Verstovsek S, Kantarjian H, Manshouri T, O'Brien S, Faderl S, Talpaz M et al. Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. Cancer. 2002 Mar 1;94(5):1517-1521. https://doi.org/10.1002/cncr.10363
Verstovsek, Srdan ; Kantarjian, Hagop ; Manshouri, Taghi ; O'Brien, Susan ; Faderl, Stefan ; Talpaz, Moshe ; Cortes, Jorge ; Albitar, Maher. / Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. In: Cancer. 2002 ; Vol. 94, No. 5. pp. 1517-1521.
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abstract = "BACKGROUND. The Tie-1 tyrosine kinase receptor and its thus far unidentified ligand appear to play a distinct role in the regulatory pathways of early hematopoiesis and angiogenesis. Because vascularity is increased in the bone marrow of patients with chronic myeloid leukemia (CML), the authors evaluated the clinical significance of Tie-1 expression in such patients. METHODS. Using Western blot analysis and solid-phase radioimmunoassay (RIA), the authors quantified Tie-1 protein in bone marrow samples from 128 patients with CML and 31 normal controls. RESULTS. The median Tie-1 RIA value of CML samples was significantly higher than in normal controls (P = 0.01). The authors found no significant differences in Tie-1 levels in patients with early chronic, late chronic, accelerated, and blastic phases (P = 0.2). High Tie-1 levels correlated with short survival in patients with early chronic phase (P = 0.003; Cox proportional hazard model) but not in patients with late chronic (P = 0.2) or accelerated/blastic (P = 0.2) phase CML. Tie-1 protein level was also prognostic when patients were separated into two groups by the median value. High Tie-1 level in early chronic phase was associated with significantly shorter survival than low Tie-1 level (median survival, 116 vs. 61 months; P = 0.03). In patients with early chronic phase CML, Tie-1 levels correlated directly with patient age (P = 0.004) and platelet count (P = 0.003), and inversely with leukocyte count (P = 0.007). Tie-1 as a predictor of survival in early chronic phase CML was independent of risk group, spleen size, age, hemoglobin, and basophil count (P = 0.03; multivariate Cox proportional hazard model). CONCLUSI0NS. The authors' findings support the hypothesis that angiogenesis may play a major role in the pathophysiology of chronic phase CML.",
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