TY - JOUR
T1 - Programming dendritic cells to induce T H 2 and tolerogenic responses
AU - Pulendran, Bali
AU - Tang, Hua
AU - Manicassamy, Santhakumar
N1 - Funding Information:
We thank H. Nakaya for assistance with the figures. We gratefully acknowledge the generous support of the US National Institutes of Health and the Bill and Melinda Gates Foundation in our work. We regret not being able to cite many relevant references because of space limitations.
PY - 2010/8
Y1 - 2010/8
N2 - A fundamental puzzle in immunology is how the immune system decides what types of immune responses to launch against different stimuli. Although much is known about control of T helper type 1 (TH1) and TH 17 responses, the mechanisms that initiate T H2 and T regulatory (T reg) responses remain obscure. Emerging studies suggest a fundamental role for the innate immune system, particularly dendritic cells (DCs), in this process. We review these studies, and suggest that the innate control of T H2 and Treg responses can be viewed as different hierarchies of organization, in which DCs, their innate receptors and signaling networks, and their interactions with other cells and local microenvironments represent different levels of the hierarchy.
AB - A fundamental puzzle in immunology is how the immune system decides what types of immune responses to launch against different stimuli. Although much is known about control of T helper type 1 (TH1) and TH 17 responses, the mechanisms that initiate T H2 and T regulatory (T reg) responses remain obscure. Emerging studies suggest a fundamental role for the innate immune system, particularly dendritic cells (DCs), in this process. We review these studies, and suggest that the innate control of T H2 and Treg responses can be viewed as different hierarchies of organization, in which DCs, their innate receptors and signaling networks, and their interactions with other cells and local microenvironments represent different levels of the hierarchy.
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U2 - 10.1038/ni.1894
DO - 10.1038/ni.1894
M3 - Review article
C2 - 20644570
AN - SCOPUS:77954932467
SN - 1529-2908
VL - 11
SP - 647
EP - 655
JO - Nature Immunology
JF - Nature Immunology
IS - 8
ER -