Promoter evolution in BK virus: Functional elements are created at sequence junctions

Rhea-Beth Markowitz, Sarah Tolbert, William S. Dynan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The archetypal strain of BK virus directed very little early gene expression compared with rearranged laboratory strains of the virus. One laboratory strain that was analyzed in detail contained newly created AP-1 binding enhancer modules spanning the junction between adjacent sequence repeats. Introduction of these sequences into the archetype activated the previously quiescent early promoter.

Original languageEnglish (US)
Pages (from-to)2411-2415
Number of pages5
JournalJournal of Virology
Volume64
Issue number5
StatePublished - Dec 1 1990
Externally publishedYes

Fingerprint

BK Virus
promoter regions
viruses
Transcription Factor AP-1
Viruses
Gene Expression
gene expression

ASJC Scopus subject areas

  • Immunology

Cite this

Promoter evolution in BK virus : Functional elements are created at sequence junctions. / Markowitz, Rhea-Beth; Tolbert, Sarah; Dynan, William S.

In: Journal of Virology, Vol. 64, No. 5, 01.12.1990, p. 2411-2415.

Research output: Contribution to journalArticle

Markowitz, Rhea-Beth ; Tolbert, Sarah ; Dynan, William S. / Promoter evolution in BK virus : Functional elements are created at sequence junctions. In: Journal of Virology. 1990 ; Vol. 64, No. 5. pp. 2411-2415.
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