Promoter evolution in BK virus: Functional elements are created at sequence junctions

R. B. Markowitz, S. Tolbert, W. S. Dynan

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The archetypal strain of BK virus directed very little early gene expression compared with rearranged laboratory strains of the virus. One laboratory strain that was analyzed in detail contained newly created AP-1 binding enhancer modules spanning the junction between adjacent sequence repeats. Introduction of these sequences into the archetype activated the previously quiescent early promoter.

Original languageEnglish (US)
Pages (from-to)2411-2415
Number of pages5
JournalJournal of Virology
Volume64
Issue number5
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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