Prospective multicenter surveillance study of funguria in hospitalized patients

Carol A. Kauffman, Jose Antonio Vazquez, Jack D. Sobel, Harry A. Gallis, David S. McKinsey, A. W. Karchmer, Alan M. Sugar, Patricia Kay Sharkey, Gilbert J. Wise, Richard Mangi, Ann Mosher, Jeannette Y. Lee, William E. Dismukes

Research output: Contribution to journalArticle

314 Citations (Scopus)

Abstract

Although fungal urinary tract infections are an increasing nosocomial problem, the significance of funguria is still not clear. This multicenter prospective surveillance study of 861 patients was undertaken to define the epidemiology, management, and outcomes of funguria. Diabetes mellitus was present in 39% of patients, urinary tract abnormalities in 37.7%, and malignancy in 22.2%; only 10.9% had no underlying illnesses. Concomitant nonfungal infections were present in 85%, 90% had received antimicrobial agents, and 83.2% had urinary tract drainage devices. Candida albicans was found in 51.8% of patients and Candida glabrata in 15.6%. Microbiological and clinical outcomes were documented for 530 (61.6%) of the 861 patients. No specific therapy for funguria was given to 155 patients, and the yeast cleared from the urine of 117 (75.5%) of them. Of the 116 patients who had a catheter removed as the only treatment, the funguria cleared in 41 (35.3%). Antifungal therapy was given to 259 patients, eradicating funguria in 130 (50.2%). The rate of eradication with fluconazole was 45.5%, and with amphotericin B bladder irrigation it was 54.4%. Only 7 patients (1.3%) had documented candidemia. The mortality rate was 19.8%, reflecting the multiple serious underlying illnesses found in these patients with funguria.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalClinical Infectious Diseases
Volume30
Issue number1
DOIs
StatePublished - Feb 7 2000

Fingerprint

Multicenter Studies
Urinary Tract
Candidemia
Candida glabrata
Fluconazole
Amphotericin B
Anti-Infective Agents
Candida albicans
Urinary Tract Infections
Drainage
Diabetes Mellitus
Epidemiology
Urinary Bladder
Therapeutics
Catheters
Yeasts
Urine
Prospective Studies
Equipment and Supplies
Mortality

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Kauffman, C. A., Vazquez, J. A., Sobel, J. D., Gallis, H. A., McKinsey, D. S., Karchmer, A. W., ... Dismukes, W. E. (2000). Prospective multicenter surveillance study of funguria in hospitalized patients. Clinical Infectious Diseases, 30(1), 14-18. https://doi.org/10.1086/313583

Prospective multicenter surveillance study of funguria in hospitalized patients. / Kauffman, Carol A.; Vazquez, Jose Antonio; Sobel, Jack D.; Gallis, Harry A.; McKinsey, David S.; Karchmer, A. W.; Sugar, Alan M.; Sharkey, Patricia Kay; Wise, Gilbert J.; Mangi, Richard; Mosher, Ann; Lee, Jeannette Y.; Dismukes, William E.

In: Clinical Infectious Diseases, Vol. 30, No. 1, 07.02.2000, p. 14-18.

Research output: Contribution to journalArticle

Kauffman, CA, Vazquez, JA, Sobel, JD, Gallis, HA, McKinsey, DS, Karchmer, AW, Sugar, AM, Sharkey, PK, Wise, GJ, Mangi, R, Mosher, A, Lee, JY & Dismukes, WE 2000, 'Prospective multicenter surveillance study of funguria in hospitalized patients', Clinical Infectious Diseases, vol. 30, no. 1, pp. 14-18. https://doi.org/10.1086/313583
Kauffman, Carol A. ; Vazquez, Jose Antonio ; Sobel, Jack D. ; Gallis, Harry A. ; McKinsey, David S. ; Karchmer, A. W. ; Sugar, Alan M. ; Sharkey, Patricia Kay ; Wise, Gilbert J. ; Mangi, Richard ; Mosher, Ann ; Lee, Jeannette Y. ; Dismukes, William E. / Prospective multicenter surveillance study of funguria in hospitalized patients. In: Clinical Infectious Diseases. 2000 ; Vol. 30, No. 1. pp. 14-18.
@article{a332457e4d9d46c69118f7f323fcb26f,
title = "Prospective multicenter surveillance study of funguria in hospitalized patients",
abstract = "Although fungal urinary tract infections are an increasing nosocomial problem, the significance of funguria is still not clear. This multicenter prospective surveillance study of 861 patients was undertaken to define the epidemiology, management, and outcomes of funguria. Diabetes mellitus was present in 39{\%} of patients, urinary tract abnormalities in 37.7{\%}, and malignancy in 22.2{\%}; only 10.9{\%} had no underlying illnesses. Concomitant nonfungal infections were present in 85{\%}, 90{\%} had received antimicrobial agents, and 83.2{\%} had urinary tract drainage devices. Candida albicans was found in 51.8{\%} of patients and Candida glabrata in 15.6{\%}. Microbiological and clinical outcomes were documented for 530 (61.6{\%}) of the 861 patients. No specific therapy for funguria was given to 155 patients, and the yeast cleared from the urine of 117 (75.5{\%}) of them. Of the 116 patients who had a catheter removed as the only treatment, the funguria cleared in 41 (35.3{\%}). Antifungal therapy was given to 259 patients, eradicating funguria in 130 (50.2{\%}). The rate of eradication with fluconazole was 45.5{\%}, and with amphotericin B bladder irrigation it was 54.4{\%}. Only 7 patients (1.3{\%}) had documented candidemia. The mortality rate was 19.8{\%}, reflecting the multiple serious underlying illnesses found in these patients with funguria.",
author = "Kauffman, {Carol A.} and Vazquez, {Jose Antonio} and Sobel, {Jack D.} and Gallis, {Harry A.} and McKinsey, {David S.} and Karchmer, {A. W.} and Sugar, {Alan M.} and Sharkey, {Patricia Kay} and Wise, {Gilbert J.} and Richard Mangi and Ann Mosher and Lee, {Jeannette Y.} and Dismukes, {William E.}",
year = "2000",
month = "2",
day = "7",
doi = "10.1086/313583",
language = "English (US)",
volume = "30",
pages = "14--18",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Prospective multicenter surveillance study of funguria in hospitalized patients

AU - Kauffman, Carol A.

AU - Vazquez, Jose Antonio

AU - Sobel, Jack D.

AU - Gallis, Harry A.

AU - McKinsey, David S.

AU - Karchmer, A. W.

AU - Sugar, Alan M.

AU - Sharkey, Patricia Kay

AU - Wise, Gilbert J.

AU - Mangi, Richard

AU - Mosher, Ann

AU - Lee, Jeannette Y.

AU - Dismukes, William E.

PY - 2000/2/7

Y1 - 2000/2/7

N2 - Although fungal urinary tract infections are an increasing nosocomial problem, the significance of funguria is still not clear. This multicenter prospective surveillance study of 861 patients was undertaken to define the epidemiology, management, and outcomes of funguria. Diabetes mellitus was present in 39% of patients, urinary tract abnormalities in 37.7%, and malignancy in 22.2%; only 10.9% had no underlying illnesses. Concomitant nonfungal infections were present in 85%, 90% had received antimicrobial agents, and 83.2% had urinary tract drainage devices. Candida albicans was found in 51.8% of patients and Candida glabrata in 15.6%. Microbiological and clinical outcomes were documented for 530 (61.6%) of the 861 patients. No specific therapy for funguria was given to 155 patients, and the yeast cleared from the urine of 117 (75.5%) of them. Of the 116 patients who had a catheter removed as the only treatment, the funguria cleared in 41 (35.3%). Antifungal therapy was given to 259 patients, eradicating funguria in 130 (50.2%). The rate of eradication with fluconazole was 45.5%, and with amphotericin B bladder irrigation it was 54.4%. Only 7 patients (1.3%) had documented candidemia. The mortality rate was 19.8%, reflecting the multiple serious underlying illnesses found in these patients with funguria.

AB - Although fungal urinary tract infections are an increasing nosocomial problem, the significance of funguria is still not clear. This multicenter prospective surveillance study of 861 patients was undertaken to define the epidemiology, management, and outcomes of funguria. Diabetes mellitus was present in 39% of patients, urinary tract abnormalities in 37.7%, and malignancy in 22.2%; only 10.9% had no underlying illnesses. Concomitant nonfungal infections were present in 85%, 90% had received antimicrobial agents, and 83.2% had urinary tract drainage devices. Candida albicans was found in 51.8% of patients and Candida glabrata in 15.6%. Microbiological and clinical outcomes were documented for 530 (61.6%) of the 861 patients. No specific therapy for funguria was given to 155 patients, and the yeast cleared from the urine of 117 (75.5%) of them. Of the 116 patients who had a catheter removed as the only treatment, the funguria cleared in 41 (35.3%). Antifungal therapy was given to 259 patients, eradicating funguria in 130 (50.2%). The rate of eradication with fluconazole was 45.5%, and with amphotericin B bladder irrigation it was 54.4%. Only 7 patients (1.3%) had documented candidemia. The mortality rate was 19.8%, reflecting the multiple serious underlying illnesses found in these patients with funguria.

UR - http://www.scopus.com/inward/record.url?scp=0033980656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033980656&partnerID=8YFLogxK

U2 - 10.1086/313583

DO - 10.1086/313583

M3 - Article

C2 - 10619726

AN - SCOPUS:0033980656

VL - 30

SP - 14

EP - 18

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 1

ER -