Protection against chemotherapy toxicity by iv hyperalimentation

B. F. Issell, M. Valdivieso, Howard A. Zaren, S. J. Dudrick, E. J. Freireich, E. W. Copeland, G. P. Bodey

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Abstract

A prospective randomized trial was conducted comparing the addition of iv hyperalimentation (IVH) to Corynebacterium parvum, isophosphamide, and adriamycin (CIA) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. Thirteen patients were entered in each treatment arm of the study and IVH was administered before and after the first course of CIA for a total of 31 days. The major dose-limiting toxic effect of CIA was leukopenia. Less myelosuppression was observed for the patients receiving IVH. The difference in the lowest recorded leukocyte and neutrophil counts between the two groups was significant (P = 0.03 and 0.01, respectively). Also, a significant decrease (P = 0.06) in nausea and vomiting associated with chemotherapy administration was found for the IVH group. The differences in toxic effects between each group were not maintained over subsequent courses of therapy when both groups received CIA alone. The prevention of the toxic effects of chemotherapy by IVH suggests a means of giving higher chemotherapy doses with the intent of increasing tumor response and patient survival.

Original languageEnglish (US)
Pages (from-to)1139-1143
Number of pages5
JournalCancer Treatment Reports
Volume62
Issue number8
StatePublished - Dec 1 1978

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Propionibacterium acnes
Ifosfamide
Doxorubicin
Poisons
Drug Therapy
Squamous Cell Neoplasms
Leukopenia
Leukocyte Count
Nausea
Vomiting
Lung Neoplasms
Neutrophils
Survival
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Issell, B. F., Valdivieso, M., Zaren, H. A., Dudrick, S. J., Freireich, E. J., Copeland, E. W., & Bodey, G. P. (1978). Protection against chemotherapy toxicity by iv hyperalimentation. Cancer Treatment Reports, 62(8), 1139-1143.

Protection against chemotherapy toxicity by iv hyperalimentation. / Issell, B. F.; Valdivieso, M.; Zaren, Howard A.; Dudrick, S. J.; Freireich, E. J.; Copeland, E. W.; Bodey, G. P.

In: Cancer Treatment Reports, Vol. 62, No. 8, 01.12.1978, p. 1139-1143.

Research output: Contribution to journalArticle

Issell, BF, Valdivieso, M, Zaren, HA, Dudrick, SJ, Freireich, EJ, Copeland, EW & Bodey, GP 1978, 'Protection against chemotherapy toxicity by iv hyperalimentation', Cancer Treatment Reports, vol. 62, no. 8, pp. 1139-1143.
Issell BF, Valdivieso M, Zaren HA, Dudrick SJ, Freireich EJ, Copeland EW et al. Protection against chemotherapy toxicity by iv hyperalimentation. Cancer Treatment Reports. 1978 Dec 1;62(8):1139-1143.
Issell, B. F. ; Valdivieso, M. ; Zaren, Howard A. ; Dudrick, S. J. ; Freireich, E. J. ; Copeland, E. W. ; Bodey, G. P. / Protection against chemotherapy toxicity by iv hyperalimentation. In: Cancer Treatment Reports. 1978 ; Vol. 62, No. 8. pp. 1139-1143.
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