Protective effect of Solanum nigrum leaves extract on immobilization stress induced changes in rat's brain

Syed Kashif Zaidi, Md Nasrul Hoda, Shams Tabrez, Shakeel Ahmed Ansari, Mohammad Alam Jafri, Mohd Shahnawaz Khan, Shirin Hasan, Mohammed H. Alqahtani, Adel Mohammed Abuzenadah, Naheed Banu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats were treated with single dose of crude extract of S. nigrum prior to and after 6 h of immobilization stress exposure. Exposure to immobilization stress resulted in a decrease in the brain levels of glutathione, SOD, GST, and catalase, with an increase in thiobarbituric acid reactive substances (TBARS) levels. Treatment of S. nigrum extract and its active constituents to both pre- and poststressed rats resulted in significant modulation in the above mentioned parameters towards their control values with a relative dominance by the latter. Brain is vulnerable to stress induced prooxidant insult due to high levels of fat content. Thus, as a safe herbal medication the S. nigrum leaves extract or its isolated constituents can be used as nutritional supplement for scavenging free radicals generated in the brain due to physical or psychological stress or any neuronal diseases per se.

Original languageEnglish (US)
Article number912450
JournalEvidence-based Complementary and Alternative Medicine
Volume2014
DOIs
StatePublished - 2014

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Solanum nigrum
Immobilization
Thiobarbituric Acid Reactive Substances
Brain
Complex Mixtures
Free Radicals
Glutathione
Antioxidants
Psychological Stress
Catalase
Lipid Peroxidation
Fats
Enzymes

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Protective effect of Solanum nigrum leaves extract on immobilization stress induced changes in rat's brain. / Zaidi, Syed Kashif; Hoda, Md Nasrul; Tabrez, Shams; Ansari, Shakeel Ahmed; Jafri, Mohammad Alam; Shahnawaz Khan, Mohd; Hasan, Shirin; Alqahtani, Mohammed H.; Mohammed Abuzenadah, Adel; Banu, Naheed.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2014, 912450, 2014.

Research output: Contribution to journalArticle

Zaidi, SK, Hoda, MN, Tabrez, S, Ansari, SA, Jafri, MA, Shahnawaz Khan, M, Hasan, S, Alqahtani, MH, Mohammed Abuzenadah, A & Banu, N 2014, 'Protective effect of Solanum nigrum leaves extract on immobilization stress induced changes in rat's brain', Evidence-based Complementary and Alternative Medicine, vol. 2014, 912450. https://doi.org/10.1155/2014/912450
Zaidi, Syed Kashif ; Hoda, Md Nasrul ; Tabrez, Shams ; Ansari, Shakeel Ahmed ; Jafri, Mohammad Alam ; Shahnawaz Khan, Mohd ; Hasan, Shirin ; Alqahtani, Mohammed H. ; Mohammed Abuzenadah, Adel ; Banu, Naheed. / Protective effect of Solanum nigrum leaves extract on immobilization stress induced changes in rat's brain. In: Evidence-based Complementary and Alternative Medicine. 2014 ; Vol. 2014.
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