Protective effects of estrogen and selective estrogen receptor modulators in the brain

Research output: Contribution to journalShort survey

191 Citations (Scopus)

Abstract

Within the last few years, there has been a growing interest in the neuroprotective effects of estrogen and the possible beneficial effects of estrogen in neurodegenerative diseases such as stroke, Alzheimer disease, and Parkinson disease. Here, we review the progress in this field, with a particular focus upon estrogen-induced protection from stroke-induced ischemic damage. The important issue of whether clinically relevant selective estrogen receptor modulators (SERMs) such as tamoxifen and raloxifene and estrogen replacement therapy can exert neuroprotection is also addressed. Although the mechanism of estrogen and SERM neuroprotection is not clearly resolved, we summarize the leading possibilities, including 1) a genomic estrogen receptor-mediated pathway that involves gene transcription, 2) a nongenomic signaling pathway involving activation of cell signalers such as mitogen-activated protein kinases and/or phosphatidylinositol-3-kinase/protein kinase B, and 3) a nonreceptor antioxidant free-radical scavenging pathway that is primarily observed with pharmacological doses of estrogen. The role of other potential mediatory factors such as growth factors and the possibility of an astrocyte role in neuroprotection is also discussed.

Original languageEnglish (US)
Pages (from-to)1379-1385
Number of pages7
JournalBiology of reproduction
Volume67
Issue number5
DOIs
StatePublished - Nov 1 2002

Fingerprint

Selective Estrogen Receptor Modulators
Estrogens
Brain
Stroke
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Estrogen Replacement Therapy
Neuroprotective Agents
Tamoxifen
Mitogen-Activated Protein Kinases
Astrocytes
Estrogen Receptors
Neurodegenerative Diseases
Free Radicals
Parkinson Disease
Intercellular Signaling Peptides and Proteins
Alzheimer Disease
Antioxidants
Pharmacology
Genes

Keywords

  • Estradiol
  • Neuroendocrinology
  • Steroid hormones

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

Cite this

Protective effects of estrogen and selective estrogen receptor modulators in the brain. / Dhandapani, Krishnan M.; Brann, Darrell W.

In: Biology of reproduction, Vol. 67, No. 5, 01.11.2002, p. 1379-1385.

Research output: Contribution to journalShort survey

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