Protein kinase Cα puts the handcuffs on epidermal keratinocyte proliferation

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

As the predominant cellular receptor for phorbol esters, protein kinase C (PKC) is assumed to play a role in epidermal carcinogenesis. Nevertheless, determining its exact role in keratinocytes has been difficult because of the existence of multiple PKC isoforms and the inherent weaknesses in methodologies used to investigate their function. In this issue, Jerome-Morais et al. describe their use of multiple in vitro, in situ, overexpression, and knockdown approaches to demonstrate that PKCα induces keratinocyte growth arrest.

Original languageEnglish (US)
Pages (from-to)2330-2332
Number of pages3
JournalJournal of Investigative Dermatology
Volume129
Issue number10
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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