Protein Phosphatase 2A

a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders

Md Nematullah, MD Nasrul Hoda, Farah Khan

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Protein phosphatase 2A (PP2A), a ubiquitously expressed serine/threonine phosphatase, is a vitally important phosphatase for the cellular system. Structurally, it is constituted of three different subunits, namely catalytic subunit (PP2Ac), structural scaffold subunit (PP2A-A), and regulatory subunit (PP2A-B). All subunits have various isoforms, and catalytic and scaffold subunits are ubiquitously expressed, whereas regulatory subunits are more specific to tissue and cell type. It is the numerous possibilities of PP2A holoenzyme assembly with varying isoform components that make it possess a dual nature of activator or the inhibitory character in different signaling pathways, namely neural developmental pathways, Akt/protein kinase B pathway, NF-kB pathway, MAPK pathway, apoptosis pathway, and cell cycle progression to name a few. Importantly, the expression of PP2A in the brain is highest among the serine phosphatases and is known to actively participate in the neural development process. However, the exact mechanism of action of PP2A is still debated and enunciating the holoenzyme components, especially the regulatory subunit of PP2A involved in regulating neural developmental process is still poorly understood. In this review, we try to throw some light on the involvement of various PP2A holoenzyme forms in the process of neurogenesis and progression of neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)1750-1761
Number of pages12
JournalMolecular Neurobiology
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Protein Phosphatase 2
Phosphoric Monoester Hydrolases
Neurodegenerative Diseases
Holoenzymes
Catalytic Domain
Protein Isoforms
Neural Pathways
Proto-Oncogene Proteins c-akt
NF-kappa B
Phosphoprotein Phosphatases
Neurogenesis
Serine
Names
Cell Cycle
Apoptosis
Brain

Keywords

  • Neurodegenerative disease
  • Neurogenesis
  • PP2A
  • Protein phosphatase

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Protein Phosphatase 2A : a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders. / Nematullah, Md; Hoda, MD Nasrul; Khan, Farah.

In: Molecular Neurobiology, Vol. 55, No. 2, 01.02.2018, p. 1750-1761.

Research output: Contribution to journalReview article

Nematullah, Md ; Hoda, MD Nasrul ; Khan, Farah. / Protein Phosphatase 2A : a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders. In: Molecular Neurobiology. 2018 ; Vol. 55, No. 2. pp. 1750-1761.
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