TY - JOUR
T1 - Protein synthesis-dependent long-term functional plasticity
T2 - Methods and techniques
AU - Sajikumar, Sreedharan
AU - Navakkode, Sheeja
AU - Frey, Julietta Uta
PY - 2005/10
Y1 - 2005/10
N2 - There is growing interest in late-LTP and late-LTD, that is, distinct forms of functional plasticity that require somatic functions such as protein synthesis in addition to the transient synaptic processes that are required for short lasting forms. Interestingly, to date only these forms of lasting plastic events could be detected in healthy, freely moving animals and thus, they are considered as physiological cellular models of learning and memory formation. Late-LTP and -LTD are characterized by 'synaptic tagging' or 'capture' and 'synaptic cross-tagging', but there are only a few laboratories that can currently perform experiments studying these properties. In brain slice work, there are many different approaches to investigate these processes using different methodological variations: some allow slices to rest for long periods before the experiment starts, others do not; some run their experiments at near to physiological temperatures, others at lower temperatures; some stimulate frequently, others do not.
AB - There is growing interest in late-LTP and late-LTD, that is, distinct forms of functional plasticity that require somatic functions such as protein synthesis in addition to the transient synaptic processes that are required for short lasting forms. Interestingly, to date only these forms of lasting plastic events could be detected in healthy, freely moving animals and thus, they are considered as physiological cellular models of learning and memory formation. Late-LTP and -LTD are characterized by 'synaptic tagging' or 'capture' and 'synaptic cross-tagging', but there are only a few laboratories that can currently perform experiments studying these properties. In brain slice work, there are many different approaches to investigate these processes using different methodological variations: some allow slices to rest for long periods before the experiment starts, others do not; some run their experiments at near to physiological temperatures, others at lower temperatures; some stimulate frequently, others do not.
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U2 - 10.1016/j.conb.2005.08.009
DO - 10.1016/j.conb.2005.08.009
M3 - Review article
C2 - 16150586
AN - SCOPUS:25844448162
SN - 0959-4388
VL - 15
SP - 607
EP - 613
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -