Proton magnetic resonance spectroscopic observations of epilepsia partialis continua in children

Yong D Park, Jerry David Allison, Kenneth L. Weiss, Joseph R. Smith, Mark R. Lee, Don W. King

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We performed magnetic resonance spectroscopy in three pediatric patients (two boys and one girl, ages 11 to 17 years) with epilepsia partialis continua. Single-voxel proton magnetic resonance spectroscopy was performed on each patient. Data were acquired from voxels of 4 or 8 cm3 from the affected hemisphere and from contralateral homologous regions. The spectral peaks of several metabolites (N-acetyl-aspartate, choline, creatine, and lactate) were measured. Neuropathologic findings revealed Rasmussen's syndrome in two children and gliosis in one. We observed increased lactate-to-creatine ratios and reduced N-acetyl-aspartate-to-creatine ratios in the affected hemispheres in all three children with epilepsia partialis continua. These data support previous reports. The largest increase in the lactate-to-creatine ratio was detected in a patient with Rasmussen's syndrome and ongoing epilepsia partialis continua at the time of measurement. The other two patients had an increase in the lactate-to-creatine ratio and a decrease in the N-acetyl-aspartate-to-creatine ratio in the affected area. The increased lactate-to-creatine ratio was associated with recurrent focal seizures from different underlying pathologies.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalJournal of Child Neurology
Volume15
Issue number11
DOIs
StatePublished - Jan 1 2000

Fingerprint

Epilepsia Partialis Continua
Creatine
Protons
Magnetic Resonance Spectroscopy
Lactic Acid
Encephalitis
Gliosis
Choline
Seizures
Pediatrics
Pathology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Proton magnetic resonance spectroscopic observations of epilepsia partialis continua in children. / Park, Yong D; Allison, Jerry David; Weiss, Kenneth L.; Smith, Joseph R.; Lee, Mark R.; King, Don W.

In: Journal of Child Neurology, Vol. 15, No. 11, 01.01.2000, p. 729-733.

Research output: Contribution to journalArticle

Park, Yong D ; Allison, Jerry David ; Weiss, Kenneth L. ; Smith, Joseph R. ; Lee, Mark R. ; King, Don W. / Proton magnetic resonance spectroscopic observations of epilepsia partialis continua in children. In: Journal of Child Neurology. 2000 ; Vol. 15, No. 11. pp. 729-733.
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