Purification of prosomatostatin-converting enzymes

Robert B. Mackin, Bryan D. Noe, Joachim Spiess

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The enzymes responsible for performing cleavage of propeptides at basic amino acids have proven difficult to characterize. Using the processing of anglerfish islet prosomatostatin (PSS) as a model system, we are pursuing the characterization of both a single basic amino acid-specific and a dibasic amino acid-specific converting enzyme. We describe here the model system and protein isolation methods that have allowed significant progress toward complete characterization of the somatostatin-generating propeptide converting enzymes (PCEs).

Original languageEnglish (US)
Pages (from-to)30-32
Number of pages3
JournalMetabolism
Volume39
Issue number9 SUPPL. 2
DOIs
StatePublished - Sep 1990
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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