Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential

Shi Qiang Gong, Li Na Niu, Lisa K. Kemp, Cynthia K.Y. Yiu, Heonjune Ryou, Yi Pin Qi, John D. Blizzard, Sergey Nikonov, Martha G. Brackett, Regina L.W. Messer, Christine D. Wu, Jing Mao, L. Bryan Brister, Frederick A. Rueggeberg, Dwayne D. Arola, David H. Pashley, Franklin R. Tay

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol-gel chemical route; these compounds possess flexible Si-O-Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.

Original languageEnglish (US)
Pages (from-to)3270-3282
Number of pages13
JournalActa biomaterialia
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2012

Fingerprint

Silanes
Methacrylates
Ammonium Compounds
Repair
Resins
Chemical analysis
Actinomyces
Silicates
Mechanical properties
Propane
Streptococcus mutans
Candida
Biofilms
Polymethyl Methacrylate
Candida albicans
Polymerization
Hydration
Sol-gels
Condensation
Polymers

Keywords

  • Antimicrobial
  • Organic modified silicate
  • Quaternary ammonium
  • Self-repair
  • Sol-gel technique

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential. / Gong, Shi Qiang; Niu, Li Na; Kemp, Lisa K.; Yiu, Cynthia K.Y.; Ryou, Heonjune; Qi, Yi Pin; Blizzard, John D.; Nikonov, Sergey; Brackett, Martha G.; Messer, Regina L.W.; Wu, Christine D.; Mao, Jing; Bryan Brister, L.; Rueggeberg, Frederick A.; Arola, Dwayne D.; Pashley, David H.; Tay, Franklin R.

In: Acta biomaterialia, Vol. 8, No. 9, 01.09.2012, p. 3270-3282.

Research output: Contribution to journalArticle

Gong, SQ, Niu, LN, Kemp, LK, Yiu, CKY, Ryou, H, Qi, YP, Blizzard, JD, Nikonov, S, Brackett, MG, Messer, RLW, Wu, CD, Mao, J, Bryan Brister, L, Rueggeberg, FA, Arola, DD, Pashley, DH & Tay, FR 2012, 'Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential', Acta biomaterialia, vol. 8, no. 9, pp. 3270-3282. https://doi.org/10.1016/j.actbio.2012.05.031
Gong, Shi Qiang ; Niu, Li Na ; Kemp, Lisa K. ; Yiu, Cynthia K.Y. ; Ryou, Heonjune ; Qi, Yi Pin ; Blizzard, John D. ; Nikonov, Sergey ; Brackett, Martha G. ; Messer, Regina L.W. ; Wu, Christine D. ; Mao, Jing ; Bryan Brister, L. ; Rueggeberg, Frederick A. ; Arola, Dwayne D. ; Pashley, David H. ; Tay, Franklin R. / Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential. In: Acta biomaterialia. 2012 ; Vol. 8, No. 9. pp. 3270-3282.
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