Race, Income, and Disease Outcomes in Juvenile Dermatomyositis

Kathryn Phillippi, Mark Hoeltzel, Angela Byun Robinson, Susan Kim, Leslie S. Abramson, Eleanor S. Anderson, Mara L. Becker, Heather Benham, Timothy Beukelman, Peter R. Blier, Hermine I. Brunner, Joni Dean, Fatma Dedeoglu, Brian M. Feldman, Polly I. Ferguson, Donald P. Goldsmith, Beth S. Gottlieb, Thomas B. Graham, Thomas A. Griffin, Hilary M. HaftelGloria C. Higgins, J. R. Hollister, Joyce J. Hsu, Anna Huttenlocher, Norman T. Ilowite, Lisa F. Imundo, Rita S Jerath, Lawrence K. Jung, Philip J. Kahn, Daniel J. Kingsbury, Kristin E. Klein, Marisa S. Klein-Gitelman, Sivia K. Lapidus, Thomas J.A. Lehman, Carol B. Lindsley, Michael A. Malloy, Deborah K. McCurdy, Eyal Muscal, Judyann C. Olson, Kathleen M. O'Neil, Karen Onel, Sampath Prahalad, Marilynn G. Punaro, C. Egla Rabinovich, Ann M. Reed, Sarah Ringold, Mary Ellen Riordan, Angela B. Robinson, Deborah Rothman, Natasha M. Ruth, Kenneth N. Schikler, Nora G. Singer, Steven Spalding, Reema H. Syed, Kathryn S. Torok, Jenna Tress, Richard K. Vehe, Emily Von Scheven, Lydia M. Walters, Jennifer E. Weiss, Pamela Weiss, Andrew J. White, Jennifer M. Woo, Ali Yalcindag, Lawrence S. Zemel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM). Study design Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry were analyzed. Demographic data included age, sex, race, annual family income, and insurance status. Clinical outcomes included muscle strength, presence of rash, calcinosis, weakness, physical function, and quality of life measures. Disease outcomes were compared based on race and income. Results Minority subjects were significantly more likely to have low annual family income and significantly worse scores on measures of physical function, disease activity, and quality of life measures. Subjects with lower annual family income had worse scores on measures of physical function, disease activity, and quality of life scores, as well as weakness. Black subjects were more likely to have calcinosis. Despite these differences in outcome measures, there were no significant differences among the racial groups in time to diagnosis or duration of disease. Using calcinosis as a marker of disease morbidity, black race, annual family income <$50000 per year, negative antinuclear antibody, and delay in diagnosis >12 months were associated with calcinosis. Conclusion Minority race and lower family income are associated with worse morbidity and outcomes in subjects with JDM. Calcinosis was more common in black subjects. Further studies are needed to examine these associations in more detail, to support efforts to address health disparities in subjects with JDM and improve disease outcomes.

Original languageEnglish (US)
Pages (from-to)38-44.e1
JournalJournal of Pediatrics
Volume184
DOIs
StatePublished - May 1 2017

Fingerprint

Calcinosis
Quality of Life
Morbidity
Insurance Coverage
Rheumatology
Muscle Strength
Juvenile dermatomyositis
Exanthema
Arthritis
Registries
Demography
Outcome Assessment (Health Care)
Health
Research

Keywords

  • JDM
  • calcinosis
  • health disparities
  • juvenile dermatomyositis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Phillippi, K., Hoeltzel, M., Byun Robinson, A., Kim, S., Abramson, L. S., Anderson, E. S., ... Zemel, L. S. (2017). Race, Income, and Disease Outcomes in Juvenile Dermatomyositis. Journal of Pediatrics, 184, 38-44.e1. https://doi.org/10.1016/j.jpeds.2017.01.046

Race, Income, and Disease Outcomes in Juvenile Dermatomyositis. / Phillippi, Kathryn; Hoeltzel, Mark; Byun Robinson, Angela; Kim, Susan; Abramson, Leslie S.; Anderson, Eleanor S.; Becker, Mara L.; Benham, Heather; Beukelman, Timothy; Blier, Peter R.; Brunner, Hermine I.; Dean, Joni; Dedeoglu, Fatma; Feldman, Brian M.; Ferguson, Polly I.; Goldsmith, Donald P.; Gottlieb, Beth S.; Graham, Thomas B.; Griffin, Thomas A.; Haftel, Hilary M.; Higgins, Gloria C.; Hollister, J. R.; Hsu, Joyce J.; Huttenlocher, Anna; Ilowite, Norman T.; Imundo, Lisa F.; Jerath, Rita S; Jung, Lawrence K.; Kahn, Philip J.; Kingsbury, Daniel J.; Klein, Kristin E.; Klein-Gitelman, Marisa S.; Lapidus, Sivia K.; Lehman, Thomas J.A.; Lindsley, Carol B.; Malloy, Michael A.; McCurdy, Deborah K.; Muscal, Eyal; Olson, Judyann C.; O'Neil, Kathleen M.; Onel, Karen; Prahalad, Sampath; Punaro, Marilynn G.; Rabinovich, C. Egla; Reed, Ann M.; Ringold, Sarah; Riordan, Mary Ellen; Robinson, Angela B.; Rothman, Deborah; Ruth, Natasha M.; Schikler, Kenneth N.; Singer, Nora G.; Spalding, Steven; Syed, Reema H.; Torok, Kathryn S.; Tress, Jenna; Vehe, Richard K.; Von Scheven, Emily; Walters, Lydia M.; Weiss, Jennifer E.; Weiss, Pamela; White, Andrew J.; Woo, Jennifer M.; Yalcindag, Ali; Zemel, Lawrence S.

In: Journal of Pediatrics, Vol. 184, 01.05.2017, p. 38-44.e1.

Research output: Contribution to journalArticle

Phillippi, K, Hoeltzel, M, Byun Robinson, A, Kim, S, Abramson, LS, Anderson, ES, Becker, ML, Benham, H, Beukelman, T, Blier, PR, Brunner, HI, Dean, J, Dedeoglu, F, Feldman, BM, Ferguson, PI, Goldsmith, DP, Gottlieb, BS, Graham, TB, Griffin, TA, Haftel, HM, Higgins, GC, Hollister, JR, Hsu, JJ, Huttenlocher, A, Ilowite, NT, Imundo, LF, Jerath, RS, Jung, LK, Kahn, PJ, Kingsbury, DJ, Klein, KE, Klein-Gitelman, MS, Lapidus, SK, Lehman, TJA, Lindsley, CB, Malloy, MA, McCurdy, DK, Muscal, E, Olson, JC, O'Neil, KM, Onel, K, Prahalad, S, Punaro, MG, Rabinovich, CE, Reed, AM, Ringold, S, Riordan, ME, Robinson, AB, Rothman, D, Ruth, NM, Schikler, KN, Singer, NG, Spalding, S, Syed, RH, Torok, KS, Tress, J, Vehe, RK, Von Scheven, E, Walters, LM, Weiss, JE, Weiss, P, White, AJ, Woo, JM, Yalcindag, A & Zemel, LS 2017, 'Race, Income, and Disease Outcomes in Juvenile Dermatomyositis', Journal of Pediatrics, vol. 184, pp. 38-44.e1. https://doi.org/10.1016/j.jpeds.2017.01.046
Phillippi K, Hoeltzel M, Byun Robinson A, Kim S, Abramson LS, Anderson ES et al. Race, Income, and Disease Outcomes in Juvenile Dermatomyositis. Journal of Pediatrics. 2017 May 1;184:38-44.e1. https://doi.org/10.1016/j.jpeds.2017.01.046
Phillippi, Kathryn ; Hoeltzel, Mark ; Byun Robinson, Angela ; Kim, Susan ; Abramson, Leslie S. ; Anderson, Eleanor S. ; Becker, Mara L. ; Benham, Heather ; Beukelman, Timothy ; Blier, Peter R. ; Brunner, Hermine I. ; Dean, Joni ; Dedeoglu, Fatma ; Feldman, Brian M. ; Ferguson, Polly I. ; Goldsmith, Donald P. ; Gottlieb, Beth S. ; Graham, Thomas B. ; Griffin, Thomas A. ; Haftel, Hilary M. ; Higgins, Gloria C. ; Hollister, J. R. ; Hsu, Joyce J. ; Huttenlocher, Anna ; Ilowite, Norman T. ; Imundo, Lisa F. ; Jerath, Rita S ; Jung, Lawrence K. ; Kahn, Philip J. ; Kingsbury, Daniel J. ; Klein, Kristin E. ; Klein-Gitelman, Marisa S. ; Lapidus, Sivia K. ; Lehman, Thomas J.A. ; Lindsley, Carol B. ; Malloy, Michael A. ; McCurdy, Deborah K. ; Muscal, Eyal ; Olson, Judyann C. ; O'Neil, Kathleen M. ; Onel, Karen ; Prahalad, Sampath ; Punaro, Marilynn G. ; Rabinovich, C. Egla ; Reed, Ann M. ; Ringold, Sarah ; Riordan, Mary Ellen ; Robinson, Angela B. ; Rothman, Deborah ; Ruth, Natasha M. ; Schikler, Kenneth N. ; Singer, Nora G. ; Spalding, Steven ; Syed, Reema H. ; Torok, Kathryn S. ; Tress, Jenna ; Vehe, Richard K. ; Von Scheven, Emily ; Walters, Lydia M. ; Weiss, Jennifer E. ; Weiss, Pamela ; White, Andrew J. ; Woo, Jennifer M. ; Yalcindag, Ali ; Zemel, Lawrence S. / Race, Income, and Disease Outcomes in Juvenile Dermatomyositis. In: Journal of Pediatrics. 2017 ; Vol. 184. pp. 38-44.e1.
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abstract = "Objective To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM). Study design Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry were analyzed. Demographic data included age, sex, race, annual family income, and insurance status. Clinical outcomes included muscle strength, presence of rash, calcinosis, weakness, physical function, and quality of life measures. Disease outcomes were compared based on race and income. Results Minority subjects were significantly more likely to have low annual family income and significantly worse scores on measures of physical function, disease activity, and quality of life measures. Subjects with lower annual family income had worse scores on measures of physical function, disease activity, and quality of life scores, as well as weakness. Black subjects were more likely to have calcinosis. Despite these differences in outcome measures, there were no significant differences among the racial groups in time to diagnosis or duration of disease. Using calcinosis as a marker of disease morbidity, black race, annual family income <$50000 per year, negative antinuclear antibody, and delay in diagnosis >12 months were associated with calcinosis. Conclusion Minority race and lower family income are associated with worse morbidity and outcomes in subjects with JDM. Calcinosis was more common in black subjects. Further studies are needed to examine these associations in more detail, to support efforts to address health disparities in subjects with JDM and improve disease outcomes.",
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T1 - Race, Income, and Disease Outcomes in Juvenile Dermatomyositis

AU - Phillippi, Kathryn

AU - Hoeltzel, Mark

AU - Byun Robinson, Angela

AU - Kim, Susan

AU - Abramson, Leslie S.

AU - Anderson, Eleanor S.

AU - Becker, Mara L.

AU - Benham, Heather

AU - Beukelman, Timothy

AU - Blier, Peter R.

AU - Brunner, Hermine I.

AU - Dean, Joni

AU - Dedeoglu, Fatma

AU - Feldman, Brian M.

AU - Ferguson, Polly I.

AU - Goldsmith, Donald P.

AU - Gottlieb, Beth S.

AU - Graham, Thomas B.

AU - Griffin, Thomas A.

AU - Haftel, Hilary M.

AU - Higgins, Gloria C.

AU - Hollister, J. R.

AU - Hsu, Joyce J.

AU - Huttenlocher, Anna

AU - Ilowite, Norman T.

AU - Imundo, Lisa F.

AU - Jerath, Rita S

AU - Jung, Lawrence K.

AU - Kahn, Philip J.

AU - Kingsbury, Daniel J.

AU - Klein, Kristin E.

AU - Klein-Gitelman, Marisa S.

AU - Lapidus, Sivia K.

AU - Lehman, Thomas J.A.

AU - Lindsley, Carol B.

AU - Malloy, Michael A.

AU - McCurdy, Deborah K.

AU - Muscal, Eyal

AU - Olson, Judyann C.

AU - O'Neil, Kathleen M.

AU - Onel, Karen

AU - Prahalad, Sampath

AU - Punaro, Marilynn G.

AU - Rabinovich, C. Egla

AU - Reed, Ann M.

AU - Ringold, Sarah

AU - Riordan, Mary Ellen

AU - Robinson, Angela B.

AU - Rothman, Deborah

AU - Ruth, Natasha M.

AU - Schikler, Kenneth N.

AU - Singer, Nora G.

AU - Spalding, Steven

AU - Syed, Reema H.

AU - Torok, Kathryn S.

AU - Tress, Jenna

AU - Vehe, Richard K.

AU - Von Scheven, Emily

AU - Walters, Lydia M.

AU - Weiss, Jennifer E.

AU - Weiss, Pamela

AU - White, Andrew J.

AU - Woo, Jennifer M.

AU - Yalcindag, Ali

AU - Zemel, Lawrence S.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM). Study design Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry were analyzed. Demographic data included age, sex, race, annual family income, and insurance status. Clinical outcomes included muscle strength, presence of rash, calcinosis, weakness, physical function, and quality of life measures. Disease outcomes were compared based on race and income. Results Minority subjects were significantly more likely to have low annual family income and significantly worse scores on measures of physical function, disease activity, and quality of life measures. Subjects with lower annual family income had worse scores on measures of physical function, disease activity, and quality of life scores, as well as weakness. Black subjects were more likely to have calcinosis. Despite these differences in outcome measures, there were no significant differences among the racial groups in time to diagnosis or duration of disease. Using calcinosis as a marker of disease morbidity, black race, annual family income <$50000 per year, negative antinuclear antibody, and delay in diagnosis >12 months were associated with calcinosis. Conclusion Minority race and lower family income are associated with worse morbidity and outcomes in subjects with JDM. Calcinosis was more common in black subjects. Further studies are needed to examine these associations in more detail, to support efforts to address health disparities in subjects with JDM and improve disease outcomes.

AB - Objective To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM). Study design Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry were analyzed. Demographic data included age, sex, race, annual family income, and insurance status. Clinical outcomes included muscle strength, presence of rash, calcinosis, weakness, physical function, and quality of life measures. Disease outcomes were compared based on race and income. Results Minority subjects were significantly more likely to have low annual family income and significantly worse scores on measures of physical function, disease activity, and quality of life measures. Subjects with lower annual family income had worse scores on measures of physical function, disease activity, and quality of life scores, as well as weakness. Black subjects were more likely to have calcinosis. Despite these differences in outcome measures, there were no significant differences among the racial groups in time to diagnosis or duration of disease. Using calcinosis as a marker of disease morbidity, black race, annual family income <$50000 per year, negative antinuclear antibody, and delay in diagnosis >12 months were associated with calcinosis. Conclusion Minority race and lower family income are associated with worse morbidity and outcomes in subjects with JDM. Calcinosis was more common in black subjects. Further studies are needed to examine these associations in more detail, to support efforts to address health disparities in subjects with JDM and improve disease outcomes.

KW - JDM

KW - calcinosis

KW - health disparities

KW - juvenile dermatomyositis

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