Race-specific association of caesarean-section delivery with body size at age 2 years

Andrea E. Cassidy-Bushrow, Ganesa Wegienka, Suzanne Havstad, Albert M. Levin, Susan V. Lynch, Dennis R. Ownby, Andrew G. Rundle, Kimberley J. Woodcroft, Edward M. Zoratti, Christine Cole Johnson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: African American children are at higher risk of obesity than White children and African American women are more likely to undergo caesarean-section (CS) delivery than White women. CS is associated with childhood obesity; however, little is known whether this relationship varies by race. We examined if the association of CS with obesity at age 2 years varied by race. Design: Longitudinal birth cohort. Setting: Birth cohort conducted in a health care system in metropolitan Detroit, Michigan with follow-up at age 2 years. Participants: 639 birth cohort participants; 367 children (57.4%) were born to African American mothers and 230 (36.0%) children were born via CS. Main Outcome Measure: Obesity defined as body mass index ≥95th percentile at age 2 years. Results: Slightly more children of African American (n=37; 10.1%) than non-African American mothers (n=18; 6.6%) were obese (P=.12). There was evidence of effect modification between race and delivery mode with obesity at age 2 years (interaction P=.020). In children of African American mothers, CS compared to vaginal birth was associated with a significantly higher odds of obesity (aOR=2.35 (95% CI: 1.16, 4.77), P=.017). In contrast, delivery mode was not associated with obesity at age 2 years in children of non-African American mothers (aOR=.47 (95% CI: .13, 1.71), P=.25). Conclusions: There is evidence for a racespecific effect of CS on obesity at age 2 years; potential underlying mechanisms may be racial differences in the developing gut microbiome or in epigenetic programming. Future research is needed to determine if this racial difference persists into later childhood.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalEthnicity and Disease
Volume26
Issue number1
DOIs
StatePublished - Dec 1 2016

Fingerprint

Body Size
Cesarean Section
African Americans
Obesity
Mothers
Parturition
Pediatric Obesity
Epigenomics
Body Mass Index
Outcome Assessment (Health Care)
Delivery of Health Care

Keywords

  • Birth Cohort
  • Childhood Obesity
  • Delivery Mode
  • Disparities
  • Race

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cassidy-Bushrow, A. E., Wegienka, G., Havstad, S., Levin, A. M., Lynch, S. V., Ownby, D. R., ... Johnson, C. C. (2016). Race-specific association of caesarean-section delivery with body size at age 2 years. Ethnicity and Disease, 26(1), 61-68. https://doi.org/10.18865/ed.26.1.61

Race-specific association of caesarean-section delivery with body size at age 2 years. / Cassidy-Bushrow, Andrea E.; Wegienka, Ganesa; Havstad, Suzanne; Levin, Albert M.; Lynch, Susan V.; Ownby, Dennis R.; Rundle, Andrew G.; Woodcroft, Kimberley J.; Zoratti, Edward M.; Johnson, Christine Cole.

In: Ethnicity and Disease, Vol. 26, No. 1, 01.12.2016, p. 61-68.

Research output: Contribution to journalArticle

Cassidy-Bushrow, AE, Wegienka, G, Havstad, S, Levin, AM, Lynch, SV, Ownby, DR, Rundle, AG, Woodcroft, KJ, Zoratti, EM & Johnson, CC 2016, 'Race-specific association of caesarean-section delivery with body size at age 2 years', Ethnicity and Disease, vol. 26, no. 1, pp. 61-68. https://doi.org/10.18865/ed.26.1.61
Cassidy-Bushrow, Andrea E. ; Wegienka, Ganesa ; Havstad, Suzanne ; Levin, Albert M. ; Lynch, Susan V. ; Ownby, Dennis R. ; Rundle, Andrew G. ; Woodcroft, Kimberley J. ; Zoratti, Edward M. ; Johnson, Christine Cole. / Race-specific association of caesarean-section delivery with body size at age 2 years. In: Ethnicity and Disease. 2016 ; Vol. 26, No. 1. pp. 61-68.
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abstract = "Objectives: African American children are at higher risk of obesity than White children and African American women are more likely to undergo caesarean-section (CS) delivery than White women. CS is associated with childhood obesity; however, little is known whether this relationship varies by race. We examined if the association of CS with obesity at age 2 years varied by race. Design: Longitudinal birth cohort. Setting: Birth cohort conducted in a health care system in metropolitan Detroit, Michigan with follow-up at age 2 years. Participants: 639 birth cohort participants; 367 children (57.4{\%}) were born to African American mothers and 230 (36.0{\%}) children were born via CS. Main Outcome Measure: Obesity defined as body mass index ≥95th percentile at age 2 years. Results: Slightly more children of African American (n=37; 10.1{\%}) than non-African American mothers (n=18; 6.6{\%}) were obese (P=.12). There was evidence of effect modification between race and delivery mode with obesity at age 2 years (interaction P=.020). In children of African American mothers, CS compared to vaginal birth was associated with a significantly higher odds of obesity (aOR=2.35 (95{\%} CI: 1.16, 4.77), P=.017). In contrast, delivery mode was not associated with obesity at age 2 years in children of non-African American mothers (aOR=.47 (95{\%} CI: .13, 1.71), P=.25). Conclusions: There is evidence for a racespecific effect of CS on obesity at age 2 years; potential underlying mechanisms may be racial differences in the developing gut microbiome or in epigenetic programming. Future research is needed to determine if this racial difference persists into later childhood.",
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