Racial differences in physiologic parameters related to asthma among middle-class children

Christine L.M. Joseph, Dennis R. Ownby, Edward L. Peterson, Christine C. Johnson

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Asthma morbidity and mortality are higher in the United States for African-American (AA) children when compared to European-American (EA) Children. Study objectives: To explore racial differences in physiologic factors associated with pediatric asthma severity. Design: Cross-sectional. Methods: We analyzed data from two groups of children in suburban Detroit, one of which contains non-urban, middle-class AA children, a group not usually included in childhood asthma studies. All children were 6 to 8 years of age. Clinical evaluations included medical history, physical examination, skin testing, spirometry, and methacholine challenge. Results: The study population (n = 560) was 14% African American, 51% of the participants were male, and the mean age was 6.8 ± 0.4 years. Socioeconomic status (parental education) was similar overall by race, although some strata-specific differences were observed. The prevalence of physician-diagnosed asthma was 10% for both AA and EA groups. AA children were more reactive to methacholine than EA children (42% vs 22%, respectively; p = 0.001), and had significantly higher total IgE than EA children (geometric mean, 60.6 vs 27.5 IU/mL; p = 0.001). Serum IgE was related to methacholine reactivity in EA children (p = 0.001), but not AA children (p = 0.73). These differences remained after adjustment for gender, age, parental education, parental smoking, and maternal smoking during pregnancy. Conclusions: Our data support previous reports of racial differences in lung volume, airway responsiveness, and serum IgE concentrations. We found a racial difference in the relationship between total serum IgE and airway responsiveness that is unreported elsewhere. Overall, our results suggest that AA children may be predisposed to asthma.

Original languageEnglish (US)
Pages (from-to)1336-1344
Number of pages9
JournalCHEST
Volume117
Issue number5
DOIs
StatePublished - Jan 1 2000

Fingerprint

Asthma
African Americans
Immunoglobulin E
Methacholine Chloride
Smoking
Serum
Education
Spirometry
Social Class
Physical Examination
Parents
Mothers
Pediatrics
Morbidity
Physicians
Pregnancy
Lung
Skin
Mortality
Population

Keywords

  • Asthma
  • Bronchial hyperresponsiveness
  • IgE
  • Race

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Racial differences in physiologic parameters related to asthma among middle-class children. / Joseph, Christine L.M.; Ownby, Dennis R.; Peterson, Edward L.; Johnson, Christine C.

In: CHEST, Vol. 117, No. 5, 01.01.2000, p. 1336-1344.

Research output: Contribution to journalArticle

Joseph, Christine L.M. ; Ownby, Dennis R. ; Peterson, Edward L. ; Johnson, Christine C. / Racial differences in physiologic parameters related to asthma among middle-class children. In: CHEST. 2000 ; Vol. 117, No. 5. pp. 1336-1344.
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