Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness

Steven P. Cohen, B. Lee Peterlin, Larry Fulton, Edward T. Neely, Connie Kurihara, Anita Gupta, Jimmy Mali, Diana C. Fu, Michael B. Jacobs, Anthony R. Plunkett, Aubrey J. Verdun, Milan P. Stojanovic, Steven Richard Hanling, Octav Constantinescu, Ronald L. White, Brian C. McLean, Paul F. Pasquina, Zirong Zhao

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Occipital neuralgia (ON) is characterized by lancinating pain and tenderness overlying the occipital nerves. Both steroid injections and pulsed radiofrequency (PRF) are used to treat ON, but few clinical trials have evaluated efficacy, and no study has compared treatments. We performed a multicenter, randomized, double-blind, comparative-effectiveness study in 81 participants with ON or migraine with occipital nerve tenderness whose aim was to determine which treatment is superior. Forty-two participants were randomized to receive local anesthetic and saline, and three 120 second cycles of PRF per targeted nerve, and 39 were randomized to receive local anesthetic mixed with deposteroid and 3 rounds of sham PRF. Patients, treating physicians, and evaluators were blinded to interventions. The PRF group experienced a greater reduction in the primary outcome measure, average occipital pain at 6 weeks (mean change from baseline-2.743 ± 2.487 vs-1.377 ± 1.970; P < 0.001), than the steroid group, which persisted through the 6-month follow-up. Comparable benefits favoring PRF were obtained for worst occipital pain through 3 months (mean change from baseline-1.925 ± 3.204 vs-0.541 ± 2.644; P 0.043), and average overall headache pain through 6 weeks (mean change from baseline-2.738 ± 2.753 vs-1.120 ± 2.1; P 0.037). Adverse events were similar between groups, and few significant differences were noted for nonpain outcomes. We conclude that although PRF can provide greater pain relief for ON and migraine with occipital nerve tenderness than steroid injections, the superior analgesia may not be accompanied by comparable improvement on other outcome measures.

Original languageEnglish (US)
Pages (from-to)2585-2594
Number of pages10
JournalPain
Volume156
Issue number12
DOIs
StatePublished - Jan 1 2015

Fingerprint

Neuralgia
Migraine Disorders
Steroids
Pain
Injections
Local Anesthetics
Outcome Assessment (Health Care)
Analgesia
Headache
Clinical Trials
Physicians
Therapeutics

Keywords

  • Headache
  • Occipital neuralgia
  • Pulsed radiofrequency
  • Steroid injection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness. / Cohen, Steven P.; Lee Peterlin, B.; Fulton, Larry; Neely, Edward T.; Kurihara, Connie; Gupta, Anita; Mali, Jimmy; Fu, Diana C.; Jacobs, Michael B.; Plunkett, Anthony R.; Verdun, Aubrey J.; Stojanovic, Milan P.; Hanling, Steven Richard; Constantinescu, Octav; White, Ronald L.; McLean, Brian C.; Pasquina, Paul F.; Zhao, Zirong.

In: Pain, Vol. 156, No. 12, 01.01.2015, p. 2585-2594.

Research output: Contribution to journalArticle

Cohen, SP, Lee Peterlin, B, Fulton, L, Neely, ET, Kurihara, C, Gupta, A, Mali, J, Fu, DC, Jacobs, MB, Plunkett, AR, Verdun, AJ, Stojanovic, MP, Hanling, SR, Constantinescu, O, White, RL, McLean, BC, Pasquina, PF & Zhao, Z 2015, 'Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness', Pain, vol. 156, no. 12, pp. 2585-2594. https://doi.org/10.1097/j.pain.0000000000000373
Cohen, Steven P. ; Lee Peterlin, B. ; Fulton, Larry ; Neely, Edward T. ; Kurihara, Connie ; Gupta, Anita ; Mali, Jimmy ; Fu, Diana C. ; Jacobs, Michael B. ; Plunkett, Anthony R. ; Verdun, Aubrey J. ; Stojanovic, Milan P. ; Hanling, Steven Richard ; Constantinescu, Octav ; White, Ronald L. ; McLean, Brian C. ; Pasquina, Paul F. ; Zhao, Zirong. / Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness. In: Pain. 2015 ; Vol. 156, No. 12. pp. 2585-2594.
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