Rapid senescence-like response after acute injury

Xiaogang Chu, Jin Wen, Raghavan Pillai Raju

Research output: Contribution to journalArticle

Abstract

Cellular senescence is a state of irreversible growth arrest. Short-term programmed senescence such as in embryonic development and slowly progressing senescence as in aging are both well described. However, acute senescence in living organisms is not well understood. We hypothesized that hemorrhagic shock injury (HI) caused by whole body hypoxia and nutrient deprivation, resulting in organ dysfunction due to severe blood loss, could lead to acute senescence in vivo. Our experiments, for the first time, demonstrate a rapidly emerged, senolytics-responsive, senescence-like response in the rat liver in less than five hr following hemorrhagic shock. We conclude that the senescence, or pseudosenescence, observed is necessary to maintain tissue homeostasis following the injury.

Original languageEnglish (US)
JournalAging Cell
DOIs
StateAccepted/In press - 2020

Keywords

  • acute senescence
  • aging
  • cell cycle
  • senescence-associated secretory phenotype

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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