Recent Advances in the Pathogenesis of Lupus Nephritis: Autoantibodies and B Cells

Wanfang Su, Michael P. Madaio

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Although many factors contribute to the clinical presentation and subsequent course of individuals with lupus nephritis, the formation of glomerular immune deposits is typically one of the initial events. In general, breakdown in immunologic tolerance leads to the production of autoreactive B and T cells that, either through direct infiltration and/or their secretory products, initiate inflammation. Immune deposition within glomeruli results in complement activation and recruitment of inflammatory cells, along with activation of endogenous renal cells. This inflammatory cascade leads to secretion of cytokines and chemokines, which in turn attract more infiltrating cells. Up-regulation of lymphoid-derived chemokines further enhance the cellular influx, augmenting inflammation and resulting in further tissue damage. The degree of inflammation is determined by the extent of this invasion along with both the systemic and local responses to the assault. This review focuses mainly on the contributions of pathogenic autoantibodies, autoreactive B cells to lupus nephritis, and potential immunologic therapies for lupus nephritis. Manipulation of both the cells and soluble mediators that initiate and perpetuate the disease are essential to suppressing autoreactivity and inflammation and preventing disease progression.

Original languageEnglish (US)
Pages (from-to)564-568
Number of pages5
JournalSeminars in Nephrology
Volume23
Issue number6
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Lupus Nephritis
Autoantibodies
B-Lymphocytes
Inflammation
Chemokines
Complement Activation
Disease Progression
Up-Regulation
Cytokines
T-Lymphocytes
Kidney
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Recent Advances in the Pathogenesis of Lupus Nephritis : Autoantibodies and B Cells. / Su, Wanfang; Madaio, Michael P.

In: Seminars in Nephrology, Vol. 23, No. 6, 01.01.2003, p. 564-568.

Research output: Contribution to journalArticle

Su, Wanfang ; Madaio, Michael P. / Recent Advances in the Pathogenesis of Lupus Nephritis : Autoantibodies and B Cells. In: Seminars in Nephrology. 2003 ; Vol. 23, No. 6. pp. 564-568.
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