Recruiting adaptive cellular stress responses for successful brain ageing

Alexis Michelle Stranahan, Mark P. Mattson

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

Successful ageing is determined in part by genetic background, but also by experiential factors associated with lifestyle and culture. Dietary, behavioural and pharmacological interventions have been identified as potential means to slow brain ageing and forestall neurodegenerative disease. Many of these interventions recruit adaptive cellular stress responses to strengthen neuronal networks and enhance plasticity. In this Science and Society article, we describe several determinants of healthy and pathological brain ageing, with insights into how these processes are accelerated or prevented. We also describe the mechanisms underlying the neuroprotective actions of exercise and nutritional interventions, with the goal of recruiting these molecular targets for the treatment and prevention of neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalNature Reviews Neuroscience
Volume13
Issue number3
DOIs
StatePublished - Mar 1 2012

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Neurodegenerative Diseases
Brain
Life Style
Pharmacology
Genetic Background

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Recruiting adaptive cellular stress responses for successful brain ageing. / Stranahan, Alexis Michelle; Mattson, Mark P.

In: Nature Reviews Neuroscience, Vol. 13, No. 3, 01.03.2012, p. 209-216.

Research output: Contribution to journalReview article

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