Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel

Richard E. Leach, James W. Burns, Elizabeth J. Dawe, Michelle D. Smithbarbour, Michael P. Diamond

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Objective: To assess the efficacy of a bioabsorbable gel for reducing primary postoperative adhesions. Design: A randomized, prospective, blinded study. Setting: Academic research environment. Animals: Forty-one New Zealand rabbits. Intervention(s): A chemically modified hyaluronate and carboxymethylcellulose (HA/CMC) gel formulation was applied to a bilateral uterine horn injury. Postoperative adhesions were assessed at a second-look laparoscopy. Main Outcome Measure(s): The uterine horn model was shown to be adhesiogenic, with 29 (70%) of 42 untreated uterine horns found to have adhesions. After gel treatment, 22 (55%) of 40 uterine horns were free of adhesions compared with 12 (30%) of 42 controls. Result(s): Animals treated with HA/CMC gel had significantly reduced postsurgical adhesion scores when compared with controls. Conclusion(s): Treatment of injured uterine horn with HA/CMC gel resulted in a significant reduction in postoperative surgical adhesions.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalFertility and sterility
Volume69
Issue number3 SUPPL. 2
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Adhesion formation
  • Carboxymethylcellulose
  • Gel barrier
  • Hyaluronate

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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