Regioselective cleavage of O-benzyl-N-arylamidoximes: Synthesis of N-aryl amidines and amidoximes

Mariappan Anbazhagan, David W. Boykin, Chad E. Stephens

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

O-Benzyl-N-arylamidoximes have been regioselectively deprotected to provide either N-aryl amidines or amidoximes. As a result, the targeted compounds can now be prepared using palladium-catalyzed N-arylation chemistry.

Original languageEnglish (US)
Pages (from-to)9089-9092
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number50
DOIs
StatePublished - Dec 9 2002
Externally publishedYes

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Keywords

  • Amidines
  • Amidoximes
  • HBr/HOAc
  • O-benzylamidoximes
  • Pd/C/EtOH

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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