Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction

Jutong Si, Michael Tanowitz, Sandra Won, Lin Mei

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits (α, β, γ or ε, and δ) is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane. ARIA (AChR inducing activity) is believed to be the trophic factor utilized by motor neurons to stimulate AChR synthesis in the subsynaptic area. ARIA stimulates tyrosine phosphorylation of the erbB proteins and activates the MAP kinase pathway which is required for the ARIA-mediated induction of AChR genes.

Original languageEnglish (US)
Pages (from-to)1497-1502
Number of pages6
JournalLife sciences
Volume62
Issue number17-18
DOIs
StatePublished - Mar 27 1998

Fingerprint

Neuregulins
Neuromuscular Junction
Cholinergic Receptors
Transcription
Genes
Phosphorylation
Gene encoding
Nicotinic Receptors
Motor Neurons
Neurons
Tyrosine
Muscle
Phosphotransferases
Membranes
Muscles
Proteins

Keywords

  • AChR
  • ARIA
  • Neuromuscular junction
  • Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction. / Si, Jutong; Tanowitz, Michael; Won, Sandra; Mei, Lin.

In: Life sciences, Vol. 62, No. 17-18, 27.03.1998, p. 1497-1502.

Research output: Contribution to journalArticle

Si, Jutong ; Tanowitz, Michael ; Won, Sandra ; Mei, Lin. / Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction. In: Life sciences. 1998 ; Vol. 62, No. 17-18. pp. 1497-1502.
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