Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction

Jutong Si, Michael Tanowitz, Sandra Won, Lin Mei

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits (α, β, γ or ε, and δ) is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane. ARIA (AChR inducing activity) is believed to be the trophic factor utilized by motor neurons to stimulate AChR synthesis in the subsynaptic area. ARIA stimulates tyrosine phosphorylation of the erbB proteins and activates the MAP kinase pathway which is required for the ARIA-mediated induction of AChR genes.

Original languageEnglish (US)
Pages (from-to)1497-1502
Number of pages6
JournalLife sciences
Volume62
Issue number17-18
DOIs
StatePublished - Mar 27 1998

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Keywords

  • AChR
  • ARIA
  • Neuromuscular junction
  • Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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